Sustainable production of radionuclidically pure antimony-119

Olson, Aeli P.; Verich, Francesca A.; Ellison, Paul A.; Aluicio-Sarduy, Eduardo; Nickles, Robert J.; Mixdorf, Jason C.; Barnhart, Todd E.; Engle, Jonathan W.

doi:10.1186/s41181-024-00303-w

Sustainable production of radionuclidically pure antimony-119

Journal Article · Tue Oct 22 00:00:00 EDT 2024 · EJNMMI Radiopharmacy and Chemistry

DOI:https://doi.org/10.1186/s41181-024-00303-w· OSTI ID:2473158

^[1]; Verich, Francesca A. ^[1]; Ellison, Paul A. ^[1]; Aluicio-Sarduy, Eduardo ^[1]; Nickles, Robert J. ^[1]; Mixdorf, Jason C. ^[1]; Barnhart, Todd E. ^[1]; Engle, Jonathan W. ^[1]

University of Wisconsin, Madison, WI (United States)

Background Radiopharmaceutical therapy (RPT) uses radionuclides that decay via one of three therapeutically relevant decay modes (alpha, beta, and internal conversion (IC) / Auger electron (AE) emission) to deliver short range, highly damaging radiation inside of diseased cells, maintaining localized dose distribution and sparing healthy cells. Antimony-119 (¹¹⁹Sb, t_1/2 = 38.19 h, EC = 100%) is one such IC/AE emitting radionuclide, previously limited to in silico computational investigation due to barriers in production, chemical separation, and chelation. A theranostic (therapeutic/diagnostic) pair can be formed with ¹¹⁹Sb’s radioisotopic imaging analogue ¹¹⁷Sb (t_1/2 = 2.80 h, E_γ = 158.6 keV, I_γ = 85.9%, β⁺ = 262.4 keV, I_β+ = 1.81%). Results Within, we report techniques for sustainable and cost-effective production of pre-clinical quality and quantity, radionuclidically pure ¹¹⁹Sb and ¹¹⁷Sb, novel low energy photon measurement techniques for ¹¹⁹Sb activity determination, and physical yields for various tin target isotopic enrichments and thicknesses using (p, n) and (d, n) nuclear reactions. Additionally, we present a two-column separation providing a radioantimony yield of 73.1% ± 6.9% (N = 3) and tin separation factor of (6.8 ± 5.5) x 10⁵ (N = 3). Apparent molar activity measurements for deuteron produced ¹¹⁷Sb using the chelator TREN-CAM were measured at 42.4 ± 25 MBq ¹¹⁷Sb/µmol (1.14 ± 0.68 mCi/µmol), and we recovered enriched ¹¹⁹Sn target material at a recycling efficiency of 80.2% ± 5.5% (N = 6) with losses of 11.6 mg ± 0.8 mg (N = 6) per production. Conclusion We report significant steps in overcoming barriers in ¹¹⁹Sb production, chemical isolation and purification, enriched target material recycling, and chelation, helping promote accessibility and application of this promising therapeutic radionuclide. We describe a method for ¹¹⁹Sb activity measurement using its low energy gamma (23.87 keV), negating the need for attenuation correction. Finally, we report the largest yet-measured ¹¹⁹Sb production yields using proton and deuteron irradiation of natural and enriched targets and radioisotopic purity > 99.8% at end of purification.

View Journal Article

Research Organization:: University of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP)

Grant/Contract Number:: SC0022032; SC0023012

OSTI ID:: 2473158

Alternate ID(s):: OSTI ID: 2475630

Journal Information:: EJNMMI Radiopharmacy and Chemistry, Journal Name: EJNMMI Radiopharmacy and Chemistry Journal Issue: 1 Vol. 9; ISSN 2365-421X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

References (20)

“Off‐Label Use” of the Siderophore Enterobactin Enables Targeted Imaging of Cancer with Radioactive Ti^(IV) Koller, Angus J.; Glaser, Owen; DeLuca, Molly C. Angewandte Chemie, Vol. 136, Issue 18 https://doi.org/10.1002/ange.202319578	journal	March 2024
Chemistry of Antimony in Radiopharmaceutical Development: Unlocking the Theranostic Potential of Sb Isotopes Grundmane, Aivija; Radchenko, Valery; Ramogida, Caterina F. ChemPlusChem https://doi.org/10.1002/cplu.202400250	journal	October 2024
Nuclear Data Sheets for A = 117 Blachot, Jean Nuclear Data Sheets, Vol. 95, Issue 3 https://doi.org/10.1006/ndsh.2002.0007	journal	March 2002
Tissue sulfhydryl groups Ellman, George L. Archives of Biochemistry and Biophysics, Vol. 82, Issue 1 https://doi.org/10.1016/0003-9861(59)90090-6	journal	May 1959
Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron Thisgaard, H.; Jensen, M. Applied Radiation and Isotopes, Vol. 67, Issue 1 https://doi.org/10.1016/j.apradiso.2008.09.003	journal	January 2009
Medium to large scale radioisotope production for targeted radiotherapy using a small PET cyclotron Thisgaard, H.; Jensen, M.; Elema, D. R. Applied Radiation and Isotopes, Vol. 69, Issue 1 https://doi.org/10.1016/j.apradiso.2010.07.019	journal	January 2011
Nuclear Data Sheets for A = 119 Symochko, D. M.; Browne, E.; Tuli, J. K. Nuclear Data Sheets, Vol. 110, Issue 11 https://doi.org/10.1016/j.nds.2009.10.003	journal	November 2009
TENDL: Complete Nuclear Data Library for Innovative Nuclear Science and Technology Koning, A. J.; Rochman, D.; Sublet, J. -Ch. Nuclear Data Sheets, Vol. 155 https://doi.org/10.1016/j.nds.2019.01.002	journal	January 2019
Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation Ellison, Paul A.; Olson, Aeli P.; Barnhart, Todd E. Nuclear Medicine and Biology, Vol. 80-81 https://doi.org/10.1016/j.nucmedbio.2019.09.001	journal	January 2020
Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations Filosofov, Dmitry; Kurakina, Elena; Radchenko, Valery Nuclear Medicine and Biology, Vol. 94-95 https://doi.org/10.1016/j.nucmedbio.2020.12.001	journal	March 2021
Catechol-Based Functionalizable Ligands for Gallium-68 Positron Emission Tomography Imaging Joaqui-Joaqui, M. Andrey; Pandey, Mukesh K.; Bansal, Aditya Inorganic Chemistry, Vol. 59, Issue 17 https://doi.org/10.1021/acs.inorgchem.0c00975	journal	August 2020
A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XX Sb(III) Complex, and Selective Chelation of Radioantimony ( ¹¹⁹ Sb) from Its Sn Target Olson, Aeli P.; Ma, Li; Feng, Yutian Inorganic Chemistry, Vol. 60, Issue 20 https://doi.org/10.1021/acs.inorgchem.1c01690	journal	October 2021
Low-energy Electron Emitters for Targeted Radiotherapy of Small Tumours No authors listed Acta Oncologica, Vol. 40, Issue 5 https://doi.org/10.1080/028418601750444141	journal	January 2001
Fityk : a general-purpose peak fitting program Wojdyr, Marcin Journal of Applied Crystallography, Vol. 43, Issue 5 https://doi.org/10.1107/S0021889810030499	journal	September 2010
Sb119-A potent Auger emitter for targeted radionuclide therapy: Sb119-A potent Auger emitter for radionuclidetherapy Thisgaard, H.; Jensen, M. Medical Physics, Vol. 35, Issue 9 https://doi.org/10.1118/1.2963993	journal	August 2008
Auger electrons for cancer therapy – a review Ku, Anthony; Facca, Valerie J.; Cai, Zhongli EJNMMI Radiopharmacy and Chemistry, Vol. 4, Issue 1 https://doi.org/10.1186/s41181-019-0075-2	journal	October 2019
Definitions of radioisotope thick target yields Otuka, Naohiko; Takács, Sandor Radiochimica Acta, Vol. 103, Issue 1 https://doi.org/10.1515/ract-2013-2234	journal	January 2015
Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119. Randhawa, Parmissa; Olson, Aeli P.; Chen, Shaohuang Current Radiopharmaceuticals, Vol. 14, Issue 4 https://doi.org/10.2174/1874471014999210111201630	journal	November 2021
Monte Carlo Evaluation of Auger Electron–Emitting Theranostic Radionuclides Falzone, Nadia; Fernández-Varea, José M.; Flux, Glenn Journal of Nuclear Medicine, Vol. 56, Issue 9 https://doi.org/10.2967/jnumed.114.153502	journal	July 2015
Marshalling the Potential of Auger Electron Radiopharmaceutical Therapy Bolcaen, Julie; Gizawy, Mohamed A.; Terry, Samantha Y. A. Journal of Nuclear Medicine, Vol. 64, Issue 9 https://doi.org/10.2967/jnumed.122.265039	journal	August 2023

Similar Records

A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target

Journal Article · Sun Oct 03 20:00:00 EDT 2021 · Inorganic Chemistry · OSTI ID:1846100

Formation of medical radioisotopes {sup 111}In, {sup 117m}Sn, {sup 124}Sb, and {sup 177}Lu in photonuclear reactions

Journal Article · Mon Jun 15 00:00:00 EDT 2015 · Physics of Atomic Nuclei · OSTI ID:22472285

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Sustainable production of radionuclidically pure antimony-119

Citation Formats

References (20)

Similar Records

Related Subjects