Experimental Evaluation of Early and Long-Term Effects of Microparticle Embolization in Two Different Mini-Pig Models. Part II: Liver

Journal Article · Fri Jun 15 04:00:00 EDT 2007 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-005-0350-3· OSTI ID:21090993

Stampfl, S; Stampfl, U; Rehnitz, C ^[1]; Schnabel, Ph ^[2]; Satzl, S; Christoph, P; Henn, C ^[1]; Thomas, F ^[3]

---

1. University of Heidelberg, Department of Diagnostic Radiology (Germany)
2. University of Heidelberg, Department of General Pathology (Germany)
3. University of Heidelberg, Department of Vascular Surgery (Germany)

Purpose. To evaluate trisacryl-gelatin microspheres (40-120 {mu}m) for acute and chronic tissue embolization in mini-pig livers. Methods. Thirteen animals were divided into four groups: group 1 (n = 3), total arterial bed occlusion with acute procedure; groups 2 to 4, chronic superselective embolization with follow-up of 1 week (group 2, n = 1), 4 weeks (group 3, n 4) or 14 weeks (group 4, n = 5). Key endpoints were homogeneity and particle distribution in acute embolizations (group 1) and necrosis and inflammation in chronic embolizations (groups 2-4) as assessed microscopically and angiographically. Results. After liver embolization, parenchymal necrosis did not occur; only signs of vessel wall disintegration were evident. The bile ducts remained intact. A distinct foreign body reaction with sparse leukocytic infiltration and giant cells was found at 14 weeks, but no signs of major inflammation were found. Particles were seen at the presinusoidal level, but no particle transportation into the sinusoids was observed. Conclusions. Embolization in mini-pig livers, using small trisacryl-gelatin microspheres, results in vessel fibrosis without parenchymal or bile duct necrosis. The most likely explanation for preservation of the parenchyma is portal inflow. Small trisacryl-gelatin microspheres may be ideal as an adjunct for chemoembolization.

• OSTI ID: 21090993
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 3 Vol. 30; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BILIARY TRACT
EVALUATION
FIBROSIS
GELATIN
INFLAMMATION
LIVER
MICROSPHERES
NECROSIS
SWINE
TUMOR CELLS