Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

Journal Article · Tue Jan 15 04:00:00 EST 2008 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-007-9213-4· OSTI ID:21090679

Xiao, Zhengwen ^[1]; Owen, Richard J; Ashforth, Robert ^[2]; Dickey, Dwayne ^[3]; Helps, Cathy ^[4]; Tulip, John ^[3]

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1. University of Alberta, Cross Cancer Institute, Department of Oncology (Canada)
2. University of Alberta, Department of Radiology and Diagnostic Imaging (Canada)
3. University of Alberta, Department of Electric Engineering (Canada)
4. Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada)

Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

• OSTI ID: 21090679
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 1 Vol. 31; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ARTERIES
DOGS
DRUGS
ILLUMINANCE
MICROSCOPY
PROSTATE
RADIOACTIVITY
RECTUM
TECHNETIUM 99
THERAPY
TOXICITY