Radionuclide localization of intraarterial infusions in head and neck cancer

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Cancer Drug Del.; (United States)

DOI:https://doi.org/10.1089/cdd.1984.1.145· OSTI ID:5732850

Baker, S R; Wheeler, R H; Ziessman, H A; Medvec, B R; Thrall, J H; Keyes, Jr, J W

The therapeutic advantage of intraarterial infusion chemotherapy depends upon delivery of a high drug concentration to the entire tumor bulk with maximum sparing of critical normal tissues. It is clear that successful application of regional therapy must include methodology to assess quantitatively and qualitatively the infused area. /sup 99m/Tc macroaggregated albumin (Tc-MAA) injected intraarterially is held on first pass in the arteriolar capillary bed, thus providing a map of blood flow distribution. Analog and digital planar images and single photon emission computed tomography (SPECT) after Tc-MAA injections provide static and transaxial tomographic images of head and neck intraarterial infusions. SPECT can be viewed as an endless movie-type display, thus producing a rotating cimematic display. These radionuclide localization techniques provide a three-dimensional delineation of the tissues infused, including subsurface details not appreciated with dye injection alone. These procedures should be considered an integral part of intraarterial therapy of head and neck cancer.

• OSTI ID: 5732850
• Journal Information: Cancer Drug Del.; (United States), Journal Name: Cancer Drug Del.; (United States) Vol. 2; ISSN CDDED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD FLOW
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
HEAD
HOURS LIVING RADIOISOTOPES
INFUSION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NECK
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES