Histologic Comparison of Vibrating Guidewire with Conventional Guidewire Technique in an Experimental Coronary In Vivo Model
- School of Medicine, University of Ioannina, Ioannina, Department of Pathology (Greece)
- University Hospital of Ioannina, Ioannina, Department of Anesthesiology (Greece)
- Schoolof Medicine, University of Ioannina, GR 451 10 Ioannina, Department of Cardiology (Greece)
- School of Medicine, University of Crete, Heraklion, Heraklion, Department ofRadiology (Greece)
- School of Medicine, University of Ioannina, GR 451 10 Ioannina, Department of Cardiology (Greece)
- School of Medicine, University of Bristol, Bristol, Department of Radiology (United Kingdom)
Purpose: To compare the damage caused by vibrating guidewire manipulation and conventional guidewire manipulation of soft coronary wires in normal sheep coronary arteries. Methods: Using an intact sheep model the two methods of passing a coronary guidewire down a normal coronary artery under fluoroscopic screening control were studied. The resulting arterial damage caused by the two techniques was studied histologically. The severity of damage was scored from 1 (no damage) to 4 (severe damage) and expressed as: (a) percentage of damaged sections, (b) mean damage score per section and (c) percentage of sections suffering the most severe degree of damage (scores 3 and 4). Results: One hundred and sixty-eight sections were studied.The percentage of damaged sections was lower in the vibrating guidewire group (p 0.004). The mean damage score and the percentage of sections with a damage score of 3 or 4 were smaller in the vibrating guidewire group than in the conventional guidewire manipulation group (p = 0.001 and p =0.009, respectively). Conclusions: Both methods of guidewire manipulation cause identifiable vascular damage. The extent and severity of damage appear greater when the guidewire is manipulated manually.
- OSTI ID:
- 21088355
- Journal Information:
- Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 5 Vol. 26; ISSN 0174-1551; ISSN CAIRDG
- Country of Publication:
- United States
- Language:
- English
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