Mannose-binding lectin gene polymorphisms and the development of coal workers' pneumoconiosis in Japan

Journal Article · Tue Jul 15 04:00:00 EDT 2008 · American Journal of Industrial Medicine

DOI:https://doi.org/10.1002/ajim.20587· OSTI ID:21073659

Wang, X T; Ohtsuka, Y; Kimura, K; Kaji, H; Saito, J; Tanino, Y; Ishida, T; Munakata, M ^[1]

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1. Fukushima Medical University, Fukushima (Japan)

Infection, immunity and genetic factors play roles in the development of coal worker's pneumoconiosis (CWP) and progressive massive fibrosis (PMF). We investigate whether the genetic polymorphisms of mannose-binding lectin (MBL), one of the key molecules of innate immunity, is associated with the susceptibility to CWP. MBL2 polymorphisms (codon54, promoter -221, and -550) were assessed for 197 patients with CWP (119 with nodular CWP and 78 with PMF) and 153 unexposed regional controls. Serum MBL concentrations were measured in 119 CWP patients. Three polymorphisms were in linkage disequilibrium for all study populations. The MBL2 genotype and haplotypes were associated with lower serum MBL levels. The frequency of such MBL2 genotype and haplotypes were significantly higher in patients with CWP compared to controls, whereas these distributions were not different between patients with nodular CWP and those with PMF. MBL2 polymorphisms and haplotypes may be one of the genetic determinants for the susceptibility of CWP.

• OSTI ID: 21073659
• Journal Information: American Journal of Industrial Medicine, Journal Name: American Journal of Industrial Medicine Journal Issue: 7 Vol. 51; ISSN AJIMD8; ISSN 0271-3586
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
COAL
COAL MINERS
DUSTS
FIBROSIS
GENES
GENOTYPE
IMMUNITY
JAPAN
LECTINS
LUNGS
MANNOSE
PERSONNEL
PNEUMOCONIOSES
SILICA