Antithetical effect of tumor necrosis factor-alpha gene polymorphism on coal workers' pneumoconiosis (CWP)

Journal Article · Fri Jul 01 04:00:00 EDT 2005 · American Journal of Industrial Medicine

DOI:https://doi.org/10.1002/ajim.20180· OSTI ID:20638607

Wang, X T; Ohtsuka, Y; Kimura, K; Muroi, M; Ishida, T; Saito, J; Munakata, M ^[1]

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1. Fukushima Medical University, Fukushima (Japan). School of Medicine

Inter-individual variation in the severity of pneumoconiosis has been described, even with the same environmental exposure. We hypothesized that TNF-alpha promoter polymorphisms associate with lung responses to environmental exposure in coal worker's pneumoconiosis (CWP) patients. We examined polymorphisms at -238, -308, and -376 in 124 patients with CWP who had similar dust exposure history and in 122 non-exposed controls. CWP patients were divided into two groups: (1) nodular CWP (n = 84): (2) progressive massive fibrosis (PMF) (n = 44). The -308 A allele frequency was higher in patients with CWP compared to controls (6.35% and 2.05%, P {lt} 0.01). It was also higher in patients with nodular CWP compared to PMF (P {lt} 0.05). Logistic regression analysis revealed that patients with the -308 A allele were 3.8 times (P = 0.036) and those with smoking habit were 2.3 times (P {lt} 0.002) more likely to have nodular CWP than PMF. Thus TNF-alpha-308 A allele might interact with smoking to enhance susceptibility to nodular CWP.

• OSTI ID: 20638607
• Journal Information: American Journal of Industrial Medicine, Journal Name: American Journal of Industrial Medicine Journal Issue: 1 Vol. 48; ISSN AJIMD8; ISSN 0271-3586
• Country of Publication: United States
• Language: English

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