skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radiation Interaction with Therapeutic Drugs and Cell Membranes

Abstract

This transient permeabilized state of the cell membrane, named the 'cell electroporation' (CE) can be used to increase cells uptake of drugs that do not readily pass cell membrane, thus enabling their cytotoxicity. The anticancer drugs, such as bleomycin (BL) and cisplatin, are the most candidates for the combined use with ionizing and non-ionizing radiation fields. The methods and installations for the cell electroporation by electron beam (EB) and microwave (MW) irradiation are presented. The viability tests of the human leukocytes under EB and MW exposure with/without the BL in the cell cultures are discussed.

Authors:
; ; ; ; ;  [1]; ; ;  [2];  [3];  [4]
  1. Accelerators Laboratory, National Institute for Lasers, Plasma and Radiation Physics, 409, Atomistilor St., 077125 Magurele (Romania)
  2. Carol Davila University of Medicine and Pharmacy, 8, Eroii Sanitari St., 050474 Bucharest (Romania)
  3. Oncology Institute Prof. A. Trestioreanu, 252, Fundeni St., 022328 Bucharest (Romania)
  4. Military Clinical Hospital, 88, Mircea Vulcanescu St., 010825 Bucharest (Romania)
Publication Date:
OSTI Identifier:
21057291
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 899; Journal Issue: 1; Conference: 6. international conference of the Balkan Physical Union, Istanbul (Turkey), 22-26 Aug 2006; Other Information: DOI: 10.1063/1.2733557; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLEOMYCIN; CELL CULTURES; CELL MEMBRANES; ELECTRON BEAMS; HUMAN POPULATIONS; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; MICROWAVE RADIATION; NEOPLASMS; TRANSIENTS; UPTAKE

Citation Formats

Martin, Diana I., Manaila, Elena N., Matei, Constantin I., Iacob, Nicusor I., Ighigeanu, Daniel I., Craciun, Gabriela D., Moisescu, Mihaela I., Savopol, Tudor D., Kovacs, Eugenia A., Cinca, Sabin A., and Margaritescu, Irina D.. Radiation Interaction with Therapeutic Drugs and Cell Membranes. United States: N. p., 2007. Web. doi:10.1063/1.2733557.
Martin, Diana I., Manaila, Elena N., Matei, Constantin I., Iacob, Nicusor I., Ighigeanu, Daniel I., Craciun, Gabriela D., Moisescu, Mihaela I., Savopol, Tudor D., Kovacs, Eugenia A., Cinca, Sabin A., & Margaritescu, Irina D.. Radiation Interaction with Therapeutic Drugs and Cell Membranes. United States. doi:10.1063/1.2733557.
Martin, Diana I., Manaila, Elena N., Matei, Constantin I., Iacob, Nicusor I., Ighigeanu, Daniel I., Craciun, Gabriela D., Moisescu, Mihaela I., Savopol, Tudor D., Kovacs, Eugenia A., Cinca, Sabin A., and Margaritescu, Irina D.. Mon . "Radiation Interaction with Therapeutic Drugs and Cell Membranes". United States. doi:10.1063/1.2733557.
@article{osti_21057291,
title = {Radiation Interaction with Therapeutic Drugs and Cell Membranes},
author = {Martin, Diana I. and Manaila, Elena N. and Matei, Constantin I. and Iacob, Nicusor I. and Ighigeanu, Daniel I. and Craciun, Gabriela D. and Moisescu, Mihaela I. and Savopol, Tudor D. and Kovacs, Eugenia A. and Cinca, Sabin A. and Margaritescu, Irina D.},
abstractNote = {This transient permeabilized state of the cell membrane, named the 'cell electroporation' (CE) can be used to increase cells uptake of drugs that do not readily pass cell membrane, thus enabling their cytotoxicity. The anticancer drugs, such as bleomycin (BL) and cisplatin, are the most candidates for the combined use with ionizing and non-ionizing radiation fields. The methods and installations for the cell electroporation by electron beam (EB) and microwave (MW) irradiation are presented. The viability tests of the human leukocytes under EB and MW exposure with/without the BL in the cell cultures are discussed.},
doi = {10.1063/1.2733557},
journal = {AIP Conference Proceedings},
number = 1,
volume = 899,
place = {United States},
year = {Mon Apr 23 00:00:00 EDT 2007},
month = {Mon Apr 23 00:00:00 EDT 2007}
}