Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed A.; Neogi, Purnima B.; Neogi, Arup; Wang, Zhiming

doi:10.1038/s41598-018-21331-y

Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

Journal Article · Tue Feb 13 00:00:00 EST 2018 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-018-21331-y· OSTI ID:1430708

Farooq, Muhammad U. ^[1]; ^[2]; Rozhkova, Elena A. ^[3]; Wali, Hussain ^[1]; Ali, Asghar ^[4]; Fateh, Ahmed A. ^[5]; Neogi, Purnima B. ^[6]; Neogi, Arup ^[7]; Wang, Zhiming ^[1]

Univ. of Electronic Science and Technology of China, Chengdu (China). Inst. of Fundamental and Frontier Science
Argonne National Lab. (ANL), Argonne, IL (United States). Materials Science Division; National Univ. of Science and Technology (MISiS), Moscow (Russian Federation)
Argonne National Lab. (ANL), Argonne, IL (United States). Nanoscience and Technology Division. Center for Nanoscale Materials
International Islamic Univ. Islamabad (Pakistan). Dept. of Physics
Univ. of Electronic Science and Technology of China, Chengdu (China). School of Life Science and Technology
Univ. of North Texas, Denton, TX (United States). Dept. of Biological Science
Univ. of North Texas, Denton, TX (United States). Dept. of Physics

Colloidal gold nanoparticles (AuNPs) are of interest as non-toxic carriers for drug delivery owing to their advanced properties, such as extensive surface-to-volume ratio and possibilities for tailoring their charge, hydrophilicity and functionality through surface chemistries. To date, various biocompatible polymers have been used for surface decoration of AuNPs to enhance their stability, payloads capacity and cellular uptake. This study describes a facile one-step method to synthesize stable AuNPs loaded with combination of two anticancer therapeutics, -bleomycin and doxorubicin. Anticancer activities, cytotoxicity, uptake and intracellular localization of the AuNPs were demonstrated in HeLa cells. We show that the therapeutic efficacy of the nanohybrid drug was strongly enhanced by the active targeting by the nanoscale delivery system to HeLa cells with a significant decrease of the half-maximal effective drug concentration, through blockage of HeLa cancer cell cycle. These results provide rationale for further progress of AuNPs-assisted combination chemotherapy using two drugs at optimized effective concentrations which act via different mechanisms thus decreasing possibilities of development of the cancer drug resistance, reduction of systemic drug toxicity and improvement of outcomes of chemotherapy.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States); National Univ. of Science and Technology (MISiS), Moscow (Russian Federation); Univ. of Electronic Science and Technology of China, Chengdu (China)

Sponsoring Organization:: Ministry of Education and Science of the Russian Federation; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Univ. of Electronic Science and Technology of China (UESTC)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1430708

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Vol. 8; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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