High Quality Image of Biomedical Object by X-ray Refraction Based Contrast Computed Tomography

Journal Article · Fri Jan 19 04:00:00 EST 2007 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.2436463· OSTI ID:21043413

Hashimoto, E ^[1]; Maksimenko, A; Hirano, K; Hyodo, K ^[2]; Sugiyama, H ^[1]; Shimao, D ^[3]; Nishino, Y; Ishikawa, T ^[4]; Yuasa, T ^[5]; Ichihara, S ^[6]; Arai, Y ^[7]; Ando, M ^[1]

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1. Department of Photon-Science, School of Advanced Studies, Graduate University for Advanced Studies (GUAS), Shonan Village, Hayama, Kanagawa 240-0193 (Japan)
2. Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)
3. Department of Health Sciences, Ibaraki prefectural University of Health Sciences, 4669-2Ami, Ami, Inashiki, Ibaraki, 300-0394 (Japan)
4. RIKEN Harima Institute, 1-1-1 Kouto, Mikazuki, Sayo, Hyogo, 679-5148 (Japan)
5. Department of Bio-system Engineering, Faculty of Engineering Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510 (Japan)
6. Dept. of Path., Nagoya Med. Center, Nat. Hospital Organization, Naka-ku, Nagoya 460-0001 (Japan)
7. Matsumoto Dental University, 1980 Hirooka, Shiojiri, Nagano (Japan)

Recently we have developed a new Computed Tomography (CT) algorithm for refraction contrast that uses the optics of diffraction-enhanced imaging. We applied this new method to visualize soft tissue which is not visualized by the current absorption based contrast. The meaning of the contrast that appears in refraction-contrast X-ray CT images must be clarified from a biologic or anatomic point of view. It has been reported that the contrast is made with the specific gravity map with a range of approximately 10 {mu}arc sec. However, the relationship between the contrast and biologic or anatomic findings has not been investigated, to our knowledge. We compared refraction-contrast X-ray CT images with microscopic X-ray images, and we evaluated refractive indexes of pathologic lesions on phase-contrast X-ray CT images. We focused our attenuation of breast cancer and lung cancer as samples. X-ray refraction based Computed Tomography was appeared to be a pathological ability to depict the boundary between cancer nest and normal tissue, and inner structure of the disease.

• OSTI ID: 21043413
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 879; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ALGORITHMS
ATTENUATION
BIOLOGICAL MATERIALS
CAT SCANNING
IMAGES
LUNGS
MAMMARY GLANDS
NEOPLASMS
REFRACTIVE INDEX
X RADIATION
X-RAY DIFFRACTION