Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Journal Article · Sun Jul 15 04:00:00 EDT 2018 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2018.03.063· OSTI ID:23065562

Barbone, Giacomo E. ^[1]; Bravin, Alberto ^[2]; Romanelli, Pantaleo ^[3]; Mittone, Alberto ^[2]; Bucci, Domenico ^[4]; others, and

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1. Department of Physics, Ludwig Maximilians University, Garching (Germany)
2. European Synchrotron Radiation Facility, Grenoble (France)
3. Department of Brain Radiosurgery, Cyberknife Center, CDI, Milan (Italy)
4. Department of Molecular Pathology, Neuropharmacology Section, I.R.C.C.S. Neuromed, Pozzilli (Italy)

Experimental neuroimaging provides a wide range of methods for the visualization of brain anatomic morphology down to subcellular detail. Still, each technique-specific detection mechanism presents compromises among the achievable field-of-view size, spatial resolution, and nervous tissue sensitivity, leading to partial sample coverage, unresolved morphologic structures, or sparse labeling of neuronal populations and often also to obligatory sample dissection or other sample invasive manipulations. X-ray phase-contrast imaging computed tomography (PCI-CT) is an experimental imaging method that simultaneously provides micrometric spatial resolution, high soft-tissue sensitivity, and ex vivo full organ rodent brain coverage without any need for sample dissection, staining or labeling, or contrast agent injection. In the present study, we explored the benefits and limitations of PCI-CT use for in vitro imaging of normal and cancerous brain neuromorphology after in vivo treatment with synchrotron-generated x-ray microbeam radiation therapy (MRT), a spatially fractionated experimental high-dose radiosurgery. The goals were visualization of the MRT effects on nervous tissue and a qualitative comparison of the results to the histologic and high-field magnetic resonance imaging findings.

• OSTI ID: 23065562
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 101; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
CONTRAST MEDIA
IN VITRO
IN VIVO
MORPHOLOGY
NEOPLASMS
NMR IMAGING
RADIOTHERAPY
RODENTS
SENSITIVITY
SPATIAL RESOLUTION
SURGERY
SYNCHROTRONS