Search of type 2 diabetes susceptibility gene on chromosome 20q
- Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo (Japan)
- Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655 (Japan)
- Division of Metabolic Diseases, The Hospital, International Medical Center of Japan, Tokyo (Japan)
- Division of Ophthalmology, The Hospital, International Medical Center of Japan, Tokyo (Japan)
- Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo (Japan)
- Department of Pathology, Research Institute, International Medical Center of Japan, Tokyo (Japan)
- President, International Medical Center of Japan, Tokyo (Japan)
Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4{alpha} (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.
- OSTI ID:
- 20991390
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 357, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2007.04.063; PII: S0006-291X(07)00790-5; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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