Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q

Journal Article · Fri Feb 15 00:00:00 EST 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.4.1484· OSTI ID:6144410

Bell, G I; Xiang, Kunsan; Newman, M V; Wu, Songhua; Cox, N J ^[1]; Wright, L G; Spielman, R S ^[2]; Fajans, S S ^[3]

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1. Univ. of Chicago, IL (United States)
2. Univ. of Pennsylvania, Philadelphia (United States)
3. Univ. of Michigan, Ann Arbor (United States)

Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent diabetes mellitus characterized by an early age of onset, usually before 25 years of age, and an autosomal dominant mode of inheritance. The largest and best-studies MODY pedigree is the TW family. The majority of the diabetic subjects in this pedigree has a reduced and delayed insulin-secretory response to glucose, and it has been proposed that this abnormal response is the manifestation of the basic genetic defect that leads to diabetes. Using DNA from members of the TW family, the authors tested more than 75 DNA markers for linkage with MODY. A DNA polymorphism in the adenosine deaminase gene (ADA) on the long arm of chromosome 20 was found to cosegregate with MODY. The maximum logarithm of adds (lod score) for linkage between MODY and ADA was 5.25 at a recombination fraction of 0.00. These results indicate that the odds are {gt}178,000:1 that the gene responsible for MODY is this family is tightly linked to the ADA gene on chromosome 20q.

• OSTI ID: 6144410
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 88:4; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
GENE REGULATION
HETEROCHROMOSOMES
GENETIC MAPPING
ADENOSINE
GLUCOSE
HUMAN POPULATIONS
LYASES
RFLPS
ALDEHYDES
CARBOHYDRATES
CHROMOSOMES
DISEASES
ENDOCRINE DISEASES
ENZYMES
HEXOSES
MAPPING
METABOLIC DISEASES
MONOSACCHARIDES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
POPULATIONS
RIBOSIDES
SACCHARIDES
550400* - Genetics