Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells

Journal Article · Tue May 01 04:00:00 EDT 2007 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2007.02.001· OSTI ID:20976927

Kim, Yongbae ^[1]; Olivi, Luisa ^[2]; Cheong, Jae Hoon ^[2]; Maertens, Alex ^[1]; Bressler, Joseph P ^[3]

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1. Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University (United States)
2. School of Pharmacy, Sahmyook University, Seoul (Korea, Republic of)
3. Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University (United States) and Kennedy-Krieger Institute, Baltimore, MD 21205 (United States)

Aluminum and other trivalent metals were shown to stimulate uptake of transferrin bound iron and nontransferrin bound iron in erytholeukemia and hepatoma cells. Because of the association between aluminum and Alzheimer's Disease, and findings of higher levels of iron in Alzheimer's disease brains, the effects of aluminum on iron homeostasis were examined in a human glial cell line. Aluminum stimulated dose- and time-dependent uptake of nontransferrin bound iron and iron bound to transferrin. A transporter was likely involved in the uptake of nontransferrin iron because uptake reached saturation, was temperature-dependent, and attenuated by inhibitors of protein synthesis. Interestingly, the effects of aluminum were not blocked by inhibitors of RNA synthesis. Aluminum also decreased the amount of iron bound to ferritin though it did not affect levels of divalent metal transporter 1. These results suggest that aluminum disrupts iron homeostasis in Brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin.

• OSTI ID: 20976927
• Journal Information: Toxicology and Applied Pharmacology, Journal Name: Toxicology and Applied Pharmacology Journal Issue: 3 Vol. 220; ISSN TXAPA9; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ALUMINIUM
BIOSYNTHESIS
BRAIN
DOSES
FERRITIN
HEPATOMAS
HOMEOSTASIS
IRON
NERVOUS SYSTEM DISEASES
RECEPTORS
RNA
TEMPERATURE DEPENDENCE
TIME DEPENDENCE
TRANSFERRIN
UPTAKE