Proton-Beam Therapy for Olfactory Neuroblastoma

Journal Article · Sun Jul 01 04:00:00 EDT 2007 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.12.071· OSTI ID:20951702

Nishimura, Hideki ^[1]; Ogino, Takashi ^[2]; Kawashima, Mitsuhiko ^[2]; Nihei, Keiji ^[2]; Arahira, Satoko ^[2]; Onozawa, Masakatsu ^[2]; Katsuta, Shoichi ^[3]; Nishio, Teiji ^[4]

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1. Department of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba (Japan) and Department of Radiology, Kobe University Graduate School of Medicine, Hyogo (Japan)
2. Department of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba (Japan)
3. Department of Radiology, National Cancer Center Hospital East, Kashiwa, Chiba (Japan)
4. Department of Radiology, Kobe University Graduate School of Medicine, Hyogo (Japan)

Purpose: To analyze the feasibility and efficacy of proton-beam therapy (PBT) for olfactory neuroblastoma (ONB) as a definitive treatment, by reviewing our preliminary experience. Olfactory neuroblastoma is a rare disease, and a standard treatment strategy has not been established. Radiation therapy for ONB is challenging because of the proximity of ONBs to critical organs. Proton-beam therapy can provide better dose distribution compared with X-ray irradiation because of its physical characteristics, and is deemed to be a feasible treatment modality. Methods and Materials: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy{sub E}), with 2.5-Gy{sub E} once-daily fractionations. Results: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. Conclusions: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study.

• OSTI ID: 20951702
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 68; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CHEMOTHERAPY
CRITICAL ORGANS
DERMATITIS
FRACTIONATED IRRADIATION
PATIENTS
PROTON BEAMS
RADIATION DOSE DISTRIBUTIONS
RADIOTHERAPY
SKULL
SURGERY