A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials

Journal Article · Sat Jul 15 04:00:00 EDT 2006 · Journal of Solid State Chemistry

OSTI ID:20905345

Fengyu, Qu ^[1]; Guangshan, Zhu ^[1]; Huiming, Lin ^[1]; Weiwei, Zhang ^[1]; Jinyu, Sun ^[1]; Shougui, Li ^[1]; Shilun, Qiu ^[1]

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1. State Key Laboratory for Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023 (China)

A series of mesoporous silica materials with similar pore sizes, different morphologies and variable pore geometries were prepared systematically. In order to control drug release, ibuprofen was employed as a model drug and the influence of morphology and pore geometry of mesoporous silica on drug release profiles was extensively studied. The mesoporous silica and drug-loaded samples were characterized by X-ray diffraction, Fourier transform IR spectroscopy, N{sub 2} adsorption and desorption, scanning electron microscopy, and transmission electron microscopy. It was found that the drug-loading amount was directly correlated to the Brunauer-Emmett-Teller surface area, pore geometry, and pore volume; while the drug release profiles could be controlled by tailoring the morphologies of mesoporous silica carriers. - Graphical abstract: The release of ibuprofen is controlled by tailoring the morphologies of mesoporous silica. The mesoporous silica and drug-loaded samples are characterized by powder X-ray diffraction, Fourier transform IR spectroscopy, N{sub 2} adsorption and desorption, scanning electron microscopy, and transmission electron microscopy. The drug-loading amount is directly correlated to the Brunauer-Emmett-Teller surface area, pore geometry, and pore volume; while the drug release profiles can be controlled by tailoring the morphologies of mesoporous silica carriers.

• OSTI ID: 20905345
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 7 Vol. 179; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
ADSORPTION
DESORPTION
DRUGS
FOURIER TRANSFORMATION
INFRARED SPECTRA
MORPHOLOGY
SCANNING ELECTRON MICROSCOPY
SILICA
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION