Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus
Journal Article
·
· Biochemical and Biophysical Research Communications
- Dept. of Biophysics and Life Sciences, Graduate School of Arts and Sciences, Univ. of Tokyo, Komaba 3-8-1, Meguro, Tokyo 153 (Japan)
- Graduate School of Integrated Arts and Sciences, Hiroshima Univ., Higashi-Hiroshima 739 (Japan)
Modulation of hippocampal synaptic plasticity by estrogen has been attracting much attention. Here, we demonstrated the rapid effect of 17{beta}-estradiol on the density and morphology of spines in the stratum oriens (s.o., basal side) and in the stratum lacunosum-moleculare (s.l.m., apical side) by imaging Lucifer Yellow-injected CA1 neurons in adult male rat hippocampal slices, because spines in s.o. and s.l.m. have been poorly understood as compared with spines in the stratum radiatum. The application of 1 nM estradiol-induced a rapid increase in the density of spines of pyramidal neurons within 2 h. This increase by estradiol was blocked by Erk MAP kinase inhibitor and estrogen receptor inhibitor in both regions. Effect of blockade by agonists of AMPA receptors and NMDA receptors was different between s.o. and s.l.m. In both regions, ER{alpha} agonist PPT induced the same enhancing effect of spinogenesis as that induced by estradiol.
- OSTI ID:
- 20857921
- Journal Information:
- Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 351; ISSN BBRCA9; ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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