Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma

Journal Article · Fri Nov 03 04:00:00 EST 2006 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2006.08.170· OSTI ID:20854550

Berger, F ^[1]; Unterholzner, S ^[2]; Diebold, J ^[3]; Knesewitsch, P ^[1]; Hahn, K ^[1]; Spitzweg, C ^[2]

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1. Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich (Germany)
2. Department of Internal Medicine II, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Ludwig-Maximilians-University, Munich (Germany)
3. Department of Pathology, Ludwig-Maximilians-University, Munich (Germany)

The sodium iodide symporter (NIS) has been characterized to mediate the active transport of iodide not only in the thyroid gland but also in various non-thyroidal tissues, including lactating mammary gland and the majority of breast cancers, thereby offering the possibility of diagnostic and therapeutic radioiodine application in breast cancer. In this report, we present a 57-year-old patient with multifocal papillary thyroid carcinoma, who showed focal radioiodine accumulation in a lesion in the right breast on a posttherapy {sup 131}I scan following radioiodine therapy. CT and MR-mammography showed a focal solid lesion in the right breast suggestive of a fibroadenoma, which was confirmed by histological examination. Immunostaining of paraffin-embedded tumor tissue sections using a human NIS antibody demonstrated NIS-specific immunoreactivity confined to epithelial cells of mammary ducts. In conclusion, in a thyroid cancer patient we identified a benign fibroadenoma of the breast expressing high levels of functionally active NIS protein as underlying cause of focal mammary radioiodine accumulation on a posttherapy {sup 131}I scan. These data show for the first time that functional NIS expression is not restricted to lactating mammary gland and malignant breast tissue, but can also be detected in benign breast lesions, such as fibroadenomata of the breast.

• OSTI ID: 20854550
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 4 Vol. 349; ISSN BBRCA9; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BIOMEDICAL RADIOGRAPHY
CARCINOMAS
IODINE 131
MAMMARY GLANDS
PARAFFIN
PATIENTS
PROTEINS
SODIUM IODIDES
THERAPY
THYROID