A novel type of EWS-CHOP fusion gene in myxoid liposarcoma
- Department of Orthopaedics, Osaka University Graduate School of Medicine (Japan)
- Department of Orthopaedics, Institute of the Health Biosciences, University of Tokushima Graduate School (Japan)
- Department of Pathology, Sapporo Medical University School of Medicine (Japan)
- Department of Pathology, Osaka University Graduate School of Medicine (Japan)
The cytogenetic hallmark of myxoid type and round cell type liposarcoma consists of reciprocal translocation of t(12;16)(q13;p11) and t(12;22)(q13;q12), which results in fusion of TLS/FUS and CHOP, and EWS and CHOP, respectively. Nine structural variations of the TLS/FUS-CHOP chimeric transcript have been reported, however, only two types of EWS-CHOP have been described. We describe here a case of myxoid liposarcoma containing a novel EWS-CHOP chimeric transcript and identified the breakpoint occurring in intron 13 of EWS. Reverse transcription-polymerase chain reaction and direct sequence showed that exon 13 of EWS was in-frame fused to exon 2 of CHOP. Genomic analysis revealed that the breaks were located in intron 13 of EWS and intron 1 of CHOP.
- OSTI ID:
- 20854468
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 348, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2006.07.085; PII: S0006-291X(06)01613-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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