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Title: Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines

Abstract

Purpose: To determine whether curcumin ameliorates acute and chronic radiation skin toxicity and to examine the expression of inflammatory cytokines (interleukin [IL]-1, IL-6, IL-18, IL-1Ra, tumor necrosis factor [TNF]-{alpha}, and lymphotoxin-{beta}) or fibrogenic cytokines (transforming growth factor [TGF]-{beta}) during the same acute and chronic phases. Methods and Materials: Curcumin was given intragastrically or intraperitoneally to C3H/HeN mice either: 5 days before radiation; 5 days after radiation; or both 5 days before and 5 days after radiation. The cutaneous damage was assessed at 15-21 days (acute) and 90 days (chronic) after a single 50 Gy radiation dose was given to the hind leg. Skin and muscle tissues were collected for measurement of cytokine mRNA. Results: Curcumin, administered before or after radiation, markedly reduced acute and chronic skin toxicity in mice (p < 0.05). Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-{alpha}, and lymphotoxin-{beta}) and the fibrogenic cytokine, TGF-{beta}, in cutaneous tissues at 21 days postradiation. Conclusion: Curcumin has a protective effect on radiation-induced cutaneous damage in mice, which is characterized by a downregulation of both inflammatory and fibrogenic cytokines in irradiated skin and muscle, particularly in the early phase after radiation. These results may providemore » the molecular basis for the application of curcumin in clinical radiation therapy.« less

Authors:
 [1];  [2];  [3];  [3];  [3];  [3];  [4];  [3];  [5];  [3]
  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY (United States). E-mail: paul_okunieff@urmc.rochester.edu
  2. Institute of Clinical Pharmacology, Fujian Medical University, Fuzhou (China)
  3. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY (United States)
  4. Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY (United States)
  5. (United States)
Publication Date:
OSTI Identifier:
20842924
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 65; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2006.03.025; PII: S0360-3016(06)00457-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; CHICKENS; CURCUMIN; DAMAGE; FIBROSIS; INFLAMMATION; LEGS; LYMPHOKINES; MICE; MUSCLES; RADIATION DOSES; RADIATION PROTECTION; RADIOTHERAPY; SKIN; TOXICITY

Citation Formats

Okunieff, Paul, Xu Jianhua, Hu Dongping, Liu Weimin, Zhang Lurong, Morrow, Gary, Pentland, Alice, Ryan, Julie L., Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, and Ding, Ivan M.D. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.03.025.
Okunieff, Paul, Xu Jianhua, Hu Dongping, Liu Weimin, Zhang Lurong, Morrow, Gary, Pentland, Alice, Ryan, Julie L., Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, & Ding, Ivan M.D. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. United States. doi:10.1016/j.ijrobp.2006.03.025.
Okunieff, Paul, Xu Jianhua, Hu Dongping, Liu Weimin, Zhang Lurong, Morrow, Gary, Pentland, Alice, Ryan, Julie L., Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, and Ding, Ivan M.D. Sat . "Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines". United States. doi:10.1016/j.ijrobp.2006.03.025.
@article{osti_20842924,
title = {Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines},
author = {Okunieff, Paul and Xu Jianhua and Hu Dongping and Liu Weimin and Zhang Lurong and Morrow, Gary and Pentland, Alice and Ryan, Julie L. and Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY and Ding, Ivan M.D.},
abstractNote = {Purpose: To determine whether curcumin ameliorates acute and chronic radiation skin toxicity and to examine the expression of inflammatory cytokines (interleukin [IL]-1, IL-6, IL-18, IL-1Ra, tumor necrosis factor [TNF]-{alpha}, and lymphotoxin-{beta}) or fibrogenic cytokines (transforming growth factor [TGF]-{beta}) during the same acute and chronic phases. Methods and Materials: Curcumin was given intragastrically or intraperitoneally to C3H/HeN mice either: 5 days before radiation; 5 days after radiation; or both 5 days before and 5 days after radiation. The cutaneous damage was assessed at 15-21 days (acute) and 90 days (chronic) after a single 50 Gy radiation dose was given to the hind leg. Skin and muscle tissues were collected for measurement of cytokine mRNA. Results: Curcumin, administered before or after radiation, markedly reduced acute and chronic skin toxicity in mice (p < 0.05). Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-{alpha}, and lymphotoxin-{beta}) and the fibrogenic cytokine, TGF-{beta}, in cutaneous tissues at 21 days postradiation. Conclusion: Curcumin has a protective effect on radiation-induced cutaneous damage in mice, which is characterized by a downregulation of both inflammatory and fibrogenic cytokines in irradiated skin and muscle, particularly in the early phase after radiation. These results may provide the molecular basis for the application of curcumin in clinical radiation therapy.},
doi = {10.1016/j.ijrobp.2006.03.025},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 65,
place = {United States},
year = {2006},
month = {7}
}