Primary spinal epidural lymphoma: Patients' profile, outcome, and prognostic factors: A multicenter Rare Cancer Network study

Journal Article · Sat Jul 01 04:00:00 EDT 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.01.002· OSTI ID:20842914

Monnard, Virginie ^[1]; Sun, Alex ^[2]; Epelbaum, Ron ^[3]; Poortmans, Philip ^[4]; Miller, Robert C ^[5]; Verschueren, Tom ^[6]; Scandolaro, Luciano ^[7]; Villa, Salvador ^[8]; Majno, Sabine Balmer ^[9]; Ostermann, Sandrine ^[1]; Ozsahin, Mahmut ^[1]; Mirimanoff, Rene-Olivier ^[1]

---

1. Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)
2. Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario (Canada)
3. Department of Oncology, Rambam Medical Centre, Haifa (Israel)
4. Department of Radiotherapy, Dr. Bernard Verbeeten Instituut, Tilburg (Netherlands)
5. Division of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)
6. Department of Radiation Oncology MAASTRO, University Hospital, Maastricht (Netherlands)
7. Department of Radiation Oncology, Ospedale Sant'Anna, Como (Italy)
8. Department of Radiation Oncology, Institut Catala d'Oncologia, Barcelona (Spain)
9. Hopital Cantonal Universitaire de Geneve (HCUGE), Geneva (Switzerland)

Purpose To assess the clinical profile, treatment outcome, and prognostic factors in primary spinal epidural lymphoma (PSEL). Methods and Materials Between 1982 and 2002, 52 consecutive patients with PSEL were treated in nine institutions of the Rare Cancer Network. Forty-eight patients had an Ann Arbor stage IE and four had a stage IIE. Forty-eight patients underwent decompressive laminectomy, all received radiotherapy (RT) with (n = 32) or without chemotherapy (n = 20). Median RT dose was 36 Gy (range, 6-50 Gy). Results Six (11%) patients progressed locally and 22 (42%) had a systemic relapse. At last follow-up, 28 patients were alive and 24 had died. The 5-year overall survival, disease-free survival, and local control were 69%, 57%, and 88%, respectively. In univariate analyses, favorable prognostic factors were younger age and complete neurologic response. Multivariate analysis showed that combined modality treatment, RT volume, total dose more than 36 Gy, tumor resection, and complete neurologic response were favorable prognostic factors. Conclusions Primary spinal epidural lymphoma has distinct clinical features and outcome, with a relatively good prognosis. After therapy, local control is excellent and systemic relapse occurs in less than half the cases. Combined modality treatment appears to be superior to RT alone.

• OSTI ID: 20842914
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 65; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
LYMPHOMAS
MULTIVARIATE ANALYSIS
PATIENTS
RADIATION DOSES
RADIOTHERAPY
SPINAL CORD