Multimodal Approach to the Management of Metastatic Epidural Spinal Cord Compression (MESCC) Due to Solid Tumors

Journal Article · Wed Dec 01 04:00:00 EST 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2009.09.038· OSTI ID:21491516

Tancioni, Flavio ^[1]; Navarria, Pierina ^[2]; Lorenzetti, Martin A ^[1]; Pedrazzoli, Paolo; Masci, Giovanna ^[3]; Mancosu, Pietro ^[2]; Alloisio, Marco ^[4]; Morenghi, Emanuela ^[5]; Santoro, Armando ^[3]; Rodriguez y Baena, Riccardo ^[1]; Scorsetti, Marta ^[2]

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1. Department of Neurosurgery, Istituto Clinico Humanitas, Milan (Italy)
2. Department of Radiation Oncology, Istituto Clinico Humanitas, Milan (Italy)
3. Department of Oncology and Hematology, Istituto Clinico Humanitas, Milan (Italy)
4. Department of Thoracic Surgery, Istituto Clinico Humanitas, Milan (Italy)
5. Statistic Unit, Istituto Clinico Humanitas, Milan (Italy)

Purpose: To assess the impact of a multidisciplinary approach for treatment of patients with metastatic epidural spinal cord compression in terms of feasibility, local control, and survival. Methods and Materials: Eighty-nine consecutive patients treated between January 2004 and December 2007 were included. The most common primary cancers were lung, breast, and kidney cancers. Ninety-eight surgical procedures were performed. Radiotherapy was performed within the first month postoperatively. Clinical outcome was evaluated by modified visual analog scale for pain, Frankel scale for neurologic deficit, and magnetic resonance imaging or computed tomography scan. Nearly all patients (93%) had back pain before treatment, whereas major or minor preoperative neurologic deficit was present in 62 cases (63%). Results: Clinical remission of pain was obtained in the vast majority of patients (91%). Improvement of neurologic deficit was observed in 45 cases (72.5%). Local relapse occurred in 10%. Median survival was 11 months (range, 0-46 months). Overall survival at 1 year was 43.6%. Type of primary tumor significantly affected survival. Conclusions: In patients with metastatic epidural spinal cord compression, the combination of surgery plus radiotherapy is feasible and provides clinical benefit in most patients. The discussion of each single case within a multidisciplinary team has been of pivotal importance in implementing the most appropriate therapeutic approach.

• OSTI ID: 21491516
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 78; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CENTRAL NERVOUS SYSTEM
COMPRESSION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
GLANDS
KIDNEYS
LUNGS
MAMMARY GLANDS
MEDICINE
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
PAIN
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SPINAL CORD
SYMPTOMS
THERAPY
TOMOGRAPHY