Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma

Journal Article · Sat Apr 01 04:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.1· OSTI ID:20793427

Oertel, Susanne ^[1]; Treiber, Martina ^[1]; Zahlten-Hinguranage, Angelika ^[2]; Eichin, Steffen ^[1]; Roeder, Falk ^[1]; Funk, Angela ^[1]; Hensley, Frank W ^[1]; Timke, Carmen ^[1]; Niethammer, Andreas G ^[1]; Huber, Peter E ^[3]; Weitz, Juergen ^[4]; Eble, Micheal J ^[5]; Buchler, Markus W ^[4]; Bernd, Ludger ^[2]; Debus, Juergen ^[1]; Krempien, Robert C ^[1]

---

1. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
2. Department of Orthopedics, University of Heidelberg, Heidelberg (Germany)
3. Department of Radiation Oncology, German Cancer Research Center, Heidelberg (Germany)
4. Department of Surgery, University of Heidelberg, Heidelberg (Germany)
5. Department of Radiation Oncology, RWTH Aachen University, Aachen (Germany)

Purpose: To analyze long-term prognosis and morbidity after limb-sparing treatment of patients with extremity soft-tissue sarcoma, with intraoperative electron boost radiotherapy (IOERT) followed by a moderate dose of external beam radiotherapy (EBRT). Methods and Materials: A total of 153 patients who were treated in a single center from 1991 to 2004 were evaluated. Median IOERT dose was 15 Gy, mean EBRT dose 43 Gy (range, 40-50.4 Gy) in conventional fractionation (1.8-2 Gy). Median duration of follow-up was 33 months. Acute toxicity was assessed with Common Toxicity Criteria; late toxic effects were scored according to European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. Results: Five-year overall survival and 5-year local control rates were 77% and 78%, respectively. Whereas tumor size, patient age, and EBRT dose did not significantly affect outcome, resection status and grading were significant for survival; resection status and IOERT dose were significant for local control. Extremity salvage until death or time of follow-up was achieved in 90% of our patients, 86% of whom showed excellent limb function without impairment in activities of daily life. Acute toxicity Grade 2-4 was observed in 23% and late toxicity Grade 2-4 in 17% of patients. Conclusions: Treatment with IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity soft-tissue sarcoma.

• OSTI ID: 20793427
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 64; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEAMS
DEATH
FRACTIONATED IRRADIATION
LIMBS
PATIENTS
PRESERVATION
RADIATION DOSES
RADIOTHERAPY
SARCOMAS
TOXICITY