Intraoperative electron-beam therapy for primary and recurrent retroperitoneal soft-tissue sarcoma

Journal Article · Sat Jul 01 04:00:00 EDT 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2006.01.028· OSTI ID:20842909

Krempien, Robert ^[1]; Roeder, Falk ^[1]; Oertel, Susanne ^[1]; Weitz, Juergen ^[2]; Hensley, Frank W ^[1]; Timke, Carmen ^[1]; Funk, Angela ^[1]; Lindel, Katja ^[1]; Harms, Wolfgang ^[1]; Buchler, Markus W ^[1]; Debus, Juergen ^[1]; Treiber, Martina ^[1]

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1. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
2. Department of Surgery, University of Heidelberg, Heidelberg (Germany)

Purpose: This study assesses the long-term outcome of patients with retroperitoneal soft-tissue sarcomas treated by maximal resection in combination with intraoperative electron-beam therapy (IOERT) and postoperative external-beam radiotherapy. Methods and Materials: From 1991 to 2004, 67 patients were treated with curative intent for primary (n = 26) or recurrent (n = 41) retroperitoneal soft-tissue sarcoma. All patients underwent maximal resection in combination with IOERT (mean dose, 15 Gy), 45 patients underwent additional postoperative EBRT, and 20 patients were previously irradiated. Results: The 5-year actuarial overall survival (OS), disease-free survival, local control (LC), and freedom from metastatic disease of all patients was 64%, 28%, 40%, and 50%, respectively. The 5-year LC inside the IOERT field was 72%. For patients who completed IOERT and EBRT after R0-resection 5-year and 10-year OS was 80%, and 5-year and 10-year LC was 100%. Only 1 of the 21 patients after R0-resection and only 8 of 34 patients after R1-resection compared with 9 of 12 patients after R2-resection experienced inside IOERT-field relapse. Grade II or higher late complications were seen in 21% of the patients, but only 2 patients required surgical intervention because of late complications. Conclusion: In selected patients, IOERT results in excellent local control and survival, with acceptable morbidity.

• OSTI ID: 20842909
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 65; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DISEASE INCIDENCE
ELECTRON BEAMS
IRRADIATION
METASTASES
PATIENTS
RADIATION DOSES
RADIOTHERAPY
SARCOMAS
SURGERY