Treatment results of chemoradiotherapy for clinical stage I (Taman) esophageal carcinoma

Journal Article · Wed Mar 15 04:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2005.1· OSTI ID:20793389

Yamada, Kazunari ^[1]; Murakami, Masao ^[2]; Okamoto, Yoshiaki ^[3]; Okuno, Yoshishige ^[1]; Nakajima, Toshifumi ^[1]; Kusumi, Fusako ^[4]; Takakuwa, Hiroshi ^[4]; Matsusue, Satoru ^[5]

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1. Department of Therapeutic Radiology, Tenri Hospital, Nara (Japan)
2. Department of Radiology, Hyogo Ion Beam Center, Hyogo (Japan)
3. Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan)
4. Department of Gastroenterology, Tenri Hospital, Nara (Japan)
5. Department of Abdominal Surgery, Tenri Hospital, Nara (Japan)

Purpose: In 1991, we started a clinical prospective trial for operable esophageal carcinoma, foreseeing organ preservation, to assess the treatment results after definitive chemoradiotherapy (Crt) for clinical Stage I (Taman) esophageal cancer. Patients and Methods: Between 1992 and 2003, 63 patients were enrolled in this study. Tumor depth was mucosal cancer (T 1a) in 23 and submucosal cancer (T 1b) in 40. Crt consisted of 55-66 Gy/50-60 fractions (median, 59.4 Gy); from 1 to 3 cycles (median, 2) of concurrent chemotherapy (Cisplatin and 5-fluorouracil), followed by high-dose-rate intraluminal brachytherapy 10-12 Gy/2-3 fractions. Results: The 5-year overall and cause-specific and disease-free survival rates were 66.4%, 76.3%, and 63.7%, respectively. The 5-year cause-specific survival rates for T 1a and T 1b cancer patients were 85.2% and 70.0%, respectively (p = 0.06). The 5-year disease-free survival rates for T 1a and T 1b were 84.4% and 50.5%, respectively (p < 0.01). Esophageal fistula as a late toxicity occurred in 2 patients (G: 1; G: 1), and esophageal stricture requiring a liquid diet occurred in 2 patients. Pericardial effusion was observed in 3 patients. Conclusion: We confirmed that patients with Taman esophageal carcinoma had their esophagus preserved in 89.2% of cases after definitive Crt, and the survival rates were equivalent to those of previous reports of surgery.

• OSTI ID: 20793389
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 64; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
CARCINOMAS
CHEMOTHERAPY
COMBINED THERAPY
DIET
DOSE RATES
ESOPHAGUS
PATIENTS
SURGERY
TOXICITY
URACILS