Long-term results of definitive radiotherapy for stage I esophageal cancer

Journal Article · Mon Aug 01 04:00:00 EDT 2005 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2004.12.042· OSTI ID:20698488

Sai, Heitetsu ^[1]; Mitsumori, Michihide ^[1]; Araki, Norio ^[1]; Mizowaki, Takashi ^[1]; Nagata, Yasushi ^[1]; Nishimura, Yasumasa ^[2]; Hiraoka, Masahiro ^[1]

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1. Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine, Kyoto (Japan)
2. Department of Radiology, Kinki University School of Medicine, Osaka (Japan)

Purpose: To analyze retrospectively the long-term results of external beam radiotherapy (RT) with or without intraluminal brachytherapy (ILBT) for patients with Stage I esophageal cancer. Methods and Materials: A total of 34 patients with esophageal squamous cell carcinoma, clinically diagnosed as having Stage I disease, were treated with definitive RT, with or without ILBT. The median age was 69 years. Seven patients were treated with external beam RT alone (median, 64 Gy), and 27 were treated with external beam RT (median, 52 Gy) plus ILBT (8-12 Gy in two to three fractions). Results: The 5-year overall survival, local relapse-free survival, and cause-specific survival rate was 58.9%, 68.4%, and 80.0%, respectively, with a median follow-up of 61 months. Of 9 patients with local recurrence after initial therapy, 7 were successfully treated, and the 5-year cumulative rate of esophagectomy was 19.6%. The 2-year local relapse-free rate for patients with and without ILBT was 79.1% and 53.6%, respectively. Conclusion: Although local recurrence was frequent within 2 years, the disease-specific survival rate was high owing to effective salvage therapy. Definitive RT is a reasonable treatment option for highly comorbid and elderly patients with Stage I esophageal cancer. The role of ILBT needs to be clarified.

• OSTI ID: 20698488
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 62; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
CARCINOMAS
ESOPHAGUS
INTERNAL IRRADIATION
PATIENTS
RADIOPHARMACEUTICALS