The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects

Journal Article · Fri Sep 23 04:00:00 EDT 2005 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2005.07.096· OSTI ID:20710987

Shin, Hyoung Doo ^[1]; Kim, Kil Soo ^[2]; Cha, Min Ho ^[3]; Yoon, Yoosik ^[3]

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1. SNP Genetics, Complex B, WooLim Lion's Valley, 371-28, Gasan-Dong, Geumcheon-Gu, Seoul 153-803 (Korea, Republic of)
2. Kirin Oriental Hospital, 38-25, Jamwon-dong, Seocho-gu, Seoul 137-905 (Korea, Republic of)
3. Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Taejon 305-811 (Korea, Republic of)

Three SNPs of UCP-1 including A-3826G, A-1766G, and Ala64Thr (G+1068A) were genotyped among 453 overweight Korean female subjects recruited from an obesity clinic. Four common haplotypes with frequency greater than 0.04 were constructed with three SNPs. For an accurate evaluation of the effects of UCP-1 polymorphism on body fat accumulation, all subjects were tested using computerized tomography to measure the cross-sectional fat tissue areas at abdominal and distal part of the body. By statistical analyses, ht4[GAA] showed a significant association with decreased abdominal fat tissue area (P = 0.02, dominant model), fat tissue area at thigh (P = 0.008, dominant model), body fat mass (P = 0.002, dominant model), and waist-to-hip ratio (P = 0.01, dominant model). In addition, ht3[GAG] was associated with the accelerated reduction of waist-to-hip ratio and body fat mass by very low calorie diet among subjects who finished one-month-weight control program (P = 0.05-0.006)

• OSTI ID: 20710987
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 335; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
COMPUTERIZED TOMOGRAPHY
DIET
EVALUATION
FATS
FEMALES
METABOLIC DISEASES
PHENOTYPE