Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: Findings from a prospective, multi-institutional, phase I/II dose-escalation study
- University of California San Francisco, San Francisco, CA (United States)
- Radiation Therapy Oncology Group, Philadelphia, PA (United States)
- Washington University, St. Louis, MO (United States)
- 3D Quality Assurance Center at Washington University St. Louis, MO (United States)
- University of Texas M.D. Anderson Cancer Center, Houston, TX (United States)
- Massachusetts General Hospital, Boston MA (United States)
Purpose: To assess the relationship between the dose to the bulb of the penis and the risk of impotence in men treated on Radiation Therapy Oncology Group (RTOG) 9406. Methods and materials: Men enrolled on a Phase I/II dose-escalation study, RTOG 9406, who were reported to be potent at entry and evaluable (n = 158) were selected for inclusion. Follow-up evaluations were scheduled every 3, 4, and 6 months for the first, second, and the third through fifth years, then annually. At each follow-up visit an assessment of potency status was made. Penile structures were defined by a single observer blinded to the potency status, using Web-based, on-line software. The dosimetry for penile structures was calculated at the Quality Assurance Center at Washington University and provided to RTOG Statistical Headquarters to determine whether there was a relationship between dose and impotence. Results: Patients whose median penile dose was {>=}52.5 Gy had a greater risk of impotence compared with those receiving <52.5 Gy (p = 0.039). In a multivariate analysis neither age, the dose to the prostate, nor the use of hormonal therapy correlated with the risk of impotence. Conclusions: Dose to the bulb of the penis seems to be associated with the risk of radiation-induced impotence.
- OSTI ID:
- 20630972
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 60, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2004.05.026; PII: S0360-3016(04)00826-0; Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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