Influence of exposure time on the biotransformation rate of benzo(a)anthracene in fish
Conference
·
OSTI ID:203632
- Utrecht Univ. (Netherlands)
- NICM, The Hague (Netherlands)
Biotransformation of PAH can yield in the formation of carcinogenic metabolites, therefore, determining the rate at which metabolites are formed is of importance to risk assessment. Biotransformation rates can be affected by inducing agents, hormonal status, temperature etc. To determine if biotransformation rates of PAH are influenced by auto-induction, juvenile fathead minnows were exposed to benzo(a)anthracene in water for various exposure times. After exposure for 5, 10, 24, 72, 168 or 336 hours no significant differences between biotransformation rates were found. The variation within each biotransformation rate was less than 20%. From these findings it is concluded that auto-induction by benzo(a)anthracene does not occur in fathead minnow.
- OSTI ID:
- 203632
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
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