Applications and statistical properties of minimum significant difference-based criterion testing in a toxicity testing program
Journal Article
·
· Environmental Toxicology and Chemistry
As a follow up to the recommendations of the September 1995 SETAC Pellston Workshop on Whole Effluent Toxicity (WET) on test methods and appropriate endpoints, this paper will discuss the applications and statistical properties of using a statistical criterion of minimum significant difference (MSD). The authors examined the upper limits of acceptable MSDs as acceptance criterion in the case of normally distributed data. The implications of this approach are examined in terms of false negative rate as well as false positive rate. Results indicated that the proposed approach has reasonable statistical properties. Reproductive data from short-term chronic WET test with Ceriodaphnia dubia tests were used to demonstrate the applications of the proposed approach. The data were collected by the North Carolina Department of Environment, Health, and Natural Resources (Raleigh, NC, USA) as part of their National Pollutant Discharge Elimination System program.
- Research Organization:
- Abt Associates Clinical Trials, Cambridge, MA (US)
- OSTI ID:
- 20075735
- Journal Information:
- Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 1 Vol. 19; ISSN 0730-7268; ISSN ETOCDK
- Country of Publication:
- United States
- Language:
- English
Similar Records
Indicators of Ceriodaphnia dubia chronic toxicity test performance and sensitivity
Chronic toxicity bioassay with ceriodaphnia dubia': (1) An evaluation of a toxicity test-based approach for determining the sources of chronic toxicity; and (2) an evaluation of culture/dilution waters and diet as determinants of test outcomes
Gender-dependent problems in toxicity tests with Ceriodaphnia dubia
Conference
·
Fri Dec 30 23:00:00 EST 1994
·
OSTI ID:31782
Chronic toxicity bioassay with ceriodaphnia dubia': (1) An evaluation of a toxicity test-based approach for determining the sources of chronic toxicity; and (2) an evaluation of culture/dilution waters and diet as determinants of test outcomes
Technical Report
·
Sun Aug 01 00:00:00 EDT 1993
·
OSTI ID:5054922
Gender-dependent problems in toxicity tests with Ceriodaphnia dubia
Journal Article
·
Tue Aug 01 00:00:00 EDT 1989
· Bulletin of Environmental Contamination and Toxicology; (USA)
·
OSTI ID:6983108