Accelerator production of Tc-99m. Targetry and radiochemistry effects on yield and purity
- Univ. of California, Davis, CA (United States); and others
The direct production of Tc-99m with accelerated protons via the {sup 100}Mo(p,2n) and/or {sup 98}Mo(p,{gamma}) reactions has been proposed as an alternative to reactor-based methods. The optimization of yield and purity is affected by the choice of proton bombarding energy, the use of enriched target materials (Mo-100 and/or Mo-98), and the availability of rapid and efficient radiochemical methods. Proton beams of 20 MeV (exit at > 10 MeV) and 40 MeV (exit at > 34MeV) have been shown to provide optimum bombarding conditions. Technetium-99m yields ranging from 12 to 20 mCi/{mu}Ah (with 20 MeV) and 16 to 30 mCi/{mu}Ah (with 40 MeV) have been extrapolated from data from natural Mo targets to the use of enriched Mo targets. Using current radiochemical techniques with computerized automated systems, the development of rapid (< 30 min.) and highly reproducible separation methods that includes efficient enriched target recovery, is possible. Under these conditions, single, multi-Curie batches of Tc-99m with > 99% radionuclidic purity are possible. Current research at UC Davis is focusing on developing this approach and determining image quality and patient dosimetry under various conditions.
- OSTI ID:
- 199713
- Report Number(s):
- CONF-941129--
- Country of Publication:
- United States
- Language:
- English
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