Diversification of JAZ‐MYC signaling function in immune metabolism

Johnson, Leah Y. D.; Major, Ian T.; Chen, Yani; Yang, Changxian; Vanegas‐Cano, Leidy J.; Howe, Gregg A.

doi:10.1111/nph.19114

Title: Diversification of JAZ‐MYC signaling function in immune metabolism

Journal Article · Tue Jul 04 00:00:00 EDT 2023 · New Phytologist

DOI:https://doi.org/10.1111/nph.19114· OSTI ID:1988193

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MSU‐DOE Plant Research Laboratory Michigan State University East Lansing MI 48824 USA, Cell and Molecular Biology Program Michigan State University East Lansing MI 48824 USA, Molecular Plant Sciences Program Michigan State University East Lansing MI 48824 USA
MSU‐DOE Plant Research Laboratory Michigan State University East Lansing MI 48824 USA
MSU‐DOE Plant Research Laboratory Michigan State University East Lansing MI 48824 USA, Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA
MSU‐DOE Plant Research Laboratory Michigan State University East Lansing MI 48824 USA, Cell and Molecular Biology Program Michigan State University East Lansing MI 48824 USA, Molecular Plant Sciences Program Michigan State University East Lansing MI 48824 USA, Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA, Plant Resilience Institute Michigan State University East Lansing MI 48824 USA

Summary Jasmonate (JA) re‐programs metabolism to confer resistance to diverse environmental threats. Jasmonate stimulates the degradation of JASMONATE ZIM‐DOMAIN (JAZ) proteins that repress the activity of MYC transcription factors. In Arabidopsis thaliana , MYC and JAZ are encoded by 4 and 13 genes, respectively. The extent to which expansion of the MYC and JAZ families has contributed to functional diversification of JA responses is not well understood. Here, we investigated the role of MYC and JAZ paralogs in controlling the production of defense compounds derived from aromatic amino acids (AAAs). Analysis of loss‐of‐function and dominant myc mutations identified MYC3 and MYC4 as the major regulators of JA‐induced tryptophan metabolism. We developed a JAZ family‐based, forward genetics approach to screen randomized jaz polymutants for allelic combinations that enhance tryptophan biosynthetic capacity. We found that mutants defective in all members ( JAZ1/2/5/6 ) of JAZ group I over‐accumulate AAA‐derived defense compounds, constitutively express marker genes for the JA–ethylene branch of immunity and are more resistant to necrotrophic pathogens but not insect herbivores. In defining JAZ and MYC paralogs that regulate the production of amino‐acid‐derived defense compounds, our results provide insight into the specificity of JA signaling in immunity.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: DE‐FG02‐91ER20021

OSTI ID:: 1988193

Alternate ID(s):: OSTI ID: 1988195

Journal Information:: New Phytologist, Journal Name: New Phytologist Vol. 239 Journal Issue: 6; ISSN 0028-646X

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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