Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module

Major, Ian T.; Yoshida, Yuki; Campos, Marcelo L.; Kapali, George; Xin, Xiu-Fang; Sugimoto, Koichi; de Oliveira Ferreira, Dalton; He, Sheng Yang; Howe, Gregg A.

doi:10.1111/nph.14638

Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module

Journal Article · Mon Jun 26 00:00:00 EDT 2017 · New Phytologist

DOI:https://doi.org/10.1111/nph.14638· OSTI ID:1425392

Major, Ian T. ^[1]; Yoshida, Yuki ^[2]; Campos, Marcelo L. ^[2]; Kapali, George ^[2]; Xin, Xiu-Fang ^[2]; Sugimoto, Koichi ^[2]; de Oliveira Ferreira, Dalton ^[2]; He, Sheng Yang ^[3]; Howe, Gregg A. ^[4]

Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory; Department of Energy-Plant Research Laboratory, Michigan State University, East Lansing, MI 48824
Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory
Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory and Plant Resilience Institute; Howard Hughes Medical Inst., East Lansing, MI (United States)
Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory and Plant Resilience Institute

The plant hormone jasmonate (JA) promotes the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins to relieve repression on diverse transcription factors (TFs) that execute JA responses. However, little is known about how combinatorial complexity among JAZ–TF interactions maintains control over myriad aspects of growth, development, reproduction, and immunity. We used loss-of-function mutations to define epistatic interactions within the core JA signaling pathway and to investigate the contribution of MYC TFs to JA responses in Arabidopsis thaliana. Constitutive JA signaling in a jaz quintuple mutant (jazQ) was largely eliminated by mutations that block JA synthesis or perception. Comparison of jazQ and a jazQ myc2 myc3 myc4 octuple mutant validated known functions of MYC2/3/4 in root growth, chlorophyll degradation,and susceptibility to the pathogen Pseudomonas syringae. We found that MYC TFs also control both the enhanced resistance of jazQ leaves to insect herbivory and restricted leaf growth of jazQ. Epistatic transcriptional profiles mirrored these phenotypes and further showed that triterpenoid biosynthetic and glucosinolate catabolic genes are up-regulated in jazQ independently of MYC TFs. Lastly, our study highlights the utility of genetic epistasis to unravel the complexities of JAZ–TF interactions and demonstrates that MYC TFs exert master control over a JAZ-repressible transcriptional hierarchy that governs growth–defense balance.

View Accepted Manuscript (DOE)

Research Organization:: Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory

Sponsoring Organization:: Brazilian National Council for Scientific and Technological Development; Japan Society for Promotion of Science Research; National Institutes of Health (NIH); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-91ER20021

OSTI ID:: 1425392

Journal Information:: New Phytologist, Journal Name: New Phytologist Journal Issue: 4 Vol. 215; ISSN 0028-646X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth Gasperini, Debora; Chételat, Aurore; Acosta, Ivan F. PLOS Genetics, Vol. 11, Issue 6 https://doi.org/10.1371/journal.pgen.1005300	journal	June 2015
Wound-Induced Endogenous Jasmonates Stunt Plant Growth by Inhibiting Mitosis Zhang, Yi; Turner, John G. PLoS ONE, Vol. 3, Issue 11 https://doi.org/10.1371/journal.pone.0003699	journal	November 2008
The Non-JAZ TIFY Protein TIFY8 from Arabidopsis thaliana Is a Transcriptional Repressor Cuéllar Pérez, Amparo; Nagels Durand, Astrid; Vanden Bossche, Robin PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0084891	journal	January 2014
Social Network: JAZ Protein Interactions Expand Our Knowledge of Jasmonate Signaling Wager, Amanda; Browse, John Frontiers in Plant Science, Vol. 3 https://doi.org/10.3389/fpls.2012.00041	journal	January 2012
Control of Carbon Assimilation and Partitioning by Jasmonate: An Accounting of Growth–Defense Tradeoffs Havko, Nathan; Major, Ian; Jewell, Jeremy Plants, Vol. 5, Issue 1 https://doi.org/10.3390/plants5010007	journal	January 2016
A new method for measuring relative growth rate can uncover the costs of defensive compounds in Arabidopsis thaliana Paul-Victor, C.; Züst, T.; Rees, M. Wiley-Blackwell https://doi.org/10.5167/uzh-35531	text	January 2010
Trade-offs between plant growth and defense against insect herbivory: an emerging mechanistic synthesis Züst, Tobias; Agrawal, Anurag A. Annual Reviews https://doi.org/10.7892/boris.98942	text	January 2017

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59 BASIC BIOLOGICAL SCIENCES
gene cluster
glucosinolate
growth–defense tradeoffs
jasmonate (JA)
plant defense
plant hormone
plant–insect interaction
triterpenoid.

Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module

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