MYC transcription factors coordinate tryptophan–dependent defence responses and compromise seed yield in Arabidopsis

Guo, Qiang; Major, Ian T.; Kapali, George; Howe, Gregg A.

doi:10.1111/nph.18293

MYC transcription factors coordinate tryptophan–dependent defence responses and compromise seed yield in Arabidopsis

Journal Article · Wed Jun 01 00:00:00 EDT 2022 · New Phytologist

DOI:https://doi.org/10.1111/nph.18293· OSTI ID:1902048

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Michigan State Univ., East Lansing, MI (United States); Michigan State University
Michigan State Univ., East Lansing, MI (United States)

Robust plant immunity negatively affects other fitness traits, including growth and seed production. Jasmonate (JA) confers broad-spectrum protection against plant consumers by stimulating the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins, which in turn relieves repression on transcription factors (TFs) coincident with reduced growth and fecundity. The molecular mechanisms underlying JA-mediated decreases in fitness remain largely unknown. To assess the contribution of MYC TFs to growth and reproductive fitness at high levels of defence, we mutated three MYC genes in a JAZ-deficient mutant (jazD) of Arabidopsis thaliana that exhibits strong defence and low seed yield. Genetic epistasis analysis showed that de-repression of MYC TFs in jazD not only conferred strong resistance to insect herbivory but also reduced shoot and root growth, fruit size and seed yield. We also provided evidence that the JAZ–MYC module coordinates the supply of tryptophan with the production of indole glucosinolates and the proliferation of endoplasmic reticulum bodies that metabolise glucosinolates through the action of b-glucosidases. Our results establish MYCs as major regulators of growth- and reproductive–defence tradeoffs and further indicate that these factors coordinate tryptophan availability with the production of amino acid-derived defence compounds.

View Accepted Manuscript (DOE)

Research Organization:: Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-91ER20021

OSTI ID:: 1902048

Journal Information:: New Phytologist, Journal Name: New Phytologist Journal Issue: 1 Vol. 236; ISSN 0028-646X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Additional file 1 of Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions Abukhalaf, Mohammad; Proksch, Carsten; Thieme, Domenika figshare https://doi.org/10.6084/m9.figshare.24531942	dataset	January 2023

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Regulation of growth-defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module

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amino acid metabolism
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MYC transcription factors coordinate tryptophan–dependent defence responses and compromise seed yield in Arabidopsis

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