Large Individual Ion FTICR Measurements from the Mid-1990s Using Reactions for Charge Determination Mass Spectrometry

Smith, Richard D.

doi:10.1021/jasms.2c00329

Large Individual Ion FTICR Measurements from the Mid-1990s Using Reactions for Charge Determination Mass Spectrometry

Journal Article · Thu Apr 06 00:00:00 EDT 2023 · Journal of the American Society for Mass Spectrometry

DOI:https://doi.org/10.1021/jasms.2c00329· OSTI ID:1984034

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Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

This article discusses from a personal and present-day perspective the first studies of large highly charged individual molecular ions that were conducted using electrospray ionization (ESI) with Fourier transform ion cyclotron resonance (FTICR) MS in the mid-1990s. These studies are distinguished from current Charge Detection Mass Spectrometry (CDMS) research primarily by their use of individual ion charge state changes due to reactions. Here this work describes the key differences in technologies and methods with present CDMS, and the likely implications of these differences. I also comment on surprising individual ion behavior observed in some measurements involving increases in charge state, as well as their possible basis, and also briefly discuss the potential utility of the reaction-based mass measurement approach used in the context of what might more globally be referred to as ‘Charge Determination Mass Spectrometry’.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1984034

Report Number(s):: PNNL-SA-179554

Journal Information:: Journal of the American Society for Mass Spectrometry, Journal Name: Journal of the American Society for Mass Spectrometry Journal Issue: 5 Vol. 34; ISSN 1044-0305

Publisher:: American Society for Mass SpectrometryCopyright Statement

Country of Publication:: United States

Language:: English

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Large Individual Ion FTICR Measurements from the Mid-1990s Using Reactions for Charge Determination Mass Spectrometry

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