Tracer localization in intracerebral gliosarcoma
- Brookhaven National Lab., Upton, NY (United States); and others
The comparative localization properties of 5 radiopharmaceuticals which have been used to image primary brain tumors were investigated in a transplanted gliosarcoma in the Fisher 344 rat. Planar and SPECT images using pinhole collimation were used to investigate localization 2-4 times between 13d and 28d after transplant Imaging studies of intravenously administered Tl-201 Cl, Tc-99m-HMPAO, -MIBI, and -DTPA, and I-123 IMT were made in 70 rats. Localization properties were measured in unirradiated (n=39) and irradiated (n=31, 22.5 Gy to brain, 14 days after transplant) control and tumor-bearing rats. Ex vivo imaging and well cup measurements were made at sacrifice. MRI was used to define tumor border ROIs. Major observations include: (1) Tl, IMT, DTPA, and MIBI show increased uptake in tumor, with tumor-to-nontumor uptake ratios (tnt) from planar pinhole ROIs ranging from 1.3{plus_minus}.1 to 2.9{plus_minus}.7 between 13 and 28 d after transplant; HMPAO shows decreased activity in tumor with tnt ranging from 0.4-0.6{plus_minus}.1; (2) high resolution SPECT provides significantly greater discrimination between tumor and nontumor uptake: SPECT tnt=10.3{plus_minus}2{sub DTPA}, 3.0{plus_minus}.3{sub IMT}, 10.5{plus_minus}2{sub MIBI}, 5.6{plus_minus}2{sub TL} and 0.4{plus_minus}.1{sub HMPAO}; planar tnt=2.2{plus_minus}.4{sub DTPA}, 1.4{plus_minus}.1{sub IMT}, 1.9{plus_minus}.4{sub MIBI}, 2.1{plus_minus}.7{sub TL}, and 0.5{plus_minus}.1{sub HMPAO}; and (3) no significant differences in uptake are seen between irradiated, more slowly growing tumors and the unirradiated tumors, and maximum tnt contrast is observed at 21 d with all radiopharmaceuticals. The study shows Tc-99m DTPA and Tc-99m MIBI to have the highest selective uptake in irradiated and unirradiated growing tumor.
- OSTI ID:
- 198078
- Report Number(s):
- CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0230
- Journal Information:
- Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
- Country of Publication:
- United States
- Language:
- English
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