Chest wall FDG accumulation in serial FDG-PET images in patients being treated for bronchogenic carcinoma with radiation

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197947

Lowe, V J; Hebert, M E; Hawk, T C ^[1]

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1. Duke Univ. Medical Center, Durham, NC (United States); and others

FDG-PET can provide information important in the clinical management of patients with suspected recurrent bronchogenic carcinoma. FDG uptake in inflammatory cells has been demonstrated. In patients treated with radiation for bronchogenic carcinoma, we noted abnormal chest wall FDG accumulation in some patients. Thus, chest wall FDG uptake in patients who had been treated with radiation was evaluated. Serial FDG-PET studies (n=37) were performed in patients (n=12) with bronchogenic carcinoma. FDG-PET studies were performed before and serially after radiation therapy in all patients. Follow-up studies were performed at 3 months (mean 73 days) in 9 patients, 6 months (mean 185 days) in 11 patients and 12 months (mean 332 days) in 5 patients. ROI`s (10-16) based on attenuation images were placed in the chest wall and activity concentrations of post-therapy studies were normalized to pre-therapy studies. Radiation therapy films were examined and radiation port locations were correlated with ROIs. A paired t-test was used to analyze ROI data. FDG uptake was described relative to mediastinal activity(1-4 scale) by observers blinded from clinical information. Clinical history of radiation fibrosis or pneumonitis was obtained. Chest wall radiation port ROI uptake was 18% higher in the first(p=0.08), 40% higher in the second(p=0.003), and 32% higher in the third post-therapy studies(p=0.04) than in non-port ROIs. In 5 patients that clinically had radiation fibrosis or pneumonitis, visual interpretation identified abnormal chest wall FDG uptake in 4/5. Radiation therapy causes increased chest wall uptake in patients being treated for bronchogenic carcinoma as far as one year after therapy and should be identified to avoid confusion with recurrent tumor.

• OSTI ID: 197947
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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