Differentiation of thoracic tumors from post-treatment changes using PET with F-18 FDG and C-11 methionine
- Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States); and others
This study was undertaken to differentiate active residual or recurrent thoracic tumors from various post-treatment changes by utilizing PET with F-18 FDG and also to compare F-18 FDG and C-11 methionine (Met) in diagnostic accuracy. We have prospectively evaluated 77 FDG-PET studies in 61 patients with histologically proven lung (37) and other thoracic (24) malignant tumors. Eleven Met-PET studies were obtained in 10 patients (three lung, seven other cancers). All patients received surgery, radiation, and/or chemotherapy, and their routine follow-up radiographic exam including CT showed suspected recurrent or residual tumors. PET studies were performed using Posicam scanner (Positron Co.) transaxial as well as reconstructed coronal or sagittal images were obtained after injection of 5-10 mCi F-18 FDG or 15-20 mCi C-11 Met following at least four hour fasting and attenuating correction. All PET images were visually inspected and correlated with radiographic studies. Standard uptake values (SUVs) were generated and compared on serial studies. Fifty-one studies had histologic correlation and all patients had at least six month follow-ups. Sensitivity, specificity and accuracy for diagnosing active thoracic tumors with FDG-PET scans were 100% (52/52), 88% (22/25) and 96% (74/77), respectively. They were 100% (7/7), 100% (4/4) and 100% (11/11), respectively with Met-PET in selected patients. Three false positive (FP) FDG cases showed active inflammation histologically. SUVs of FDG-PET were 6.5{plus_minus}2.9 for true positives and 1.4{plus_minus}1.3 for true negatives, respectively. SUVs of Met-PET were 4.3{plus_minus}2.3 for TP and 1.2{plus_minus}0.5 for TN, respectively. In conclusion, PET with FDG or Met is useful in diagnosing active thoracic tumors after various treatments, and FDG showed greater SUV than Met.
- OSTI ID:
- 197946
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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