Diagnostic evaluation of solitary pulmonary nodules (SPNs) using PET-FDG imaging

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197944

Gupta, N; Chandramouli, B; Reeb, S ^[1]

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1. Creighton Univ., Omaha, NE (United States); and others

We have reported high sensitivity of PET-FDG imaging in detecting malignancy in SPNs. We now report clinical utility of PET-FDG imaging in pre-intervention workup of 66 pts (age 24-89 yrs) with radiographically indeterminate SPNs (0.5-3 cm) in size. All pts had PET imaging performed 1 hr after injection of 10 mCi of F-18 FDG. Images were analyzed qualitatively and semi-quantitatively to compute DUR indices using ROI analysis. Final diagnosis was established by histology in 65/66 pts (thoracotomy 47, needle biopsy 13, bronchoscopy 5, stable nodule 1). PET-FDG imaging demonstrates sensitivity, specificity and predictive accuracy of 94%, 87% and 92% respectively. All 3 false negative cases were SPNs <1.5 cm in size and histologically adenoca. True positive malignant SPNs were adenoca 18, small cell 5, squamous cell 12, nonsmall cell 7, and others 6. Among 15 benign lesions (granuloma 6, histoplasmosis 4, nonspecific inflammation 2, hamartoma 1, stable nodule 1, organizing pneumonia 1), 2 false positive cases were seen in histoplasmosis. In 10 patients hilar/mediastinal lymph node lesions were accurately classified as benign (5) or malignant (5). Mean DUR in malignant lesions (5.41{plus_minus}2.63) was significantly greater (p value <0.001) than benign lesions (1.12{plus_minus}0.78). In conclusion, PET-FDG imaging is highly accurate in differentiating benign from malignant lung modules and lymph node lesions. PET-FDG imaging may thus optimize surgical management of pts with radiographically SPNs.

• OSTI ID: 197944
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOPSY
FLUORINE 18
FLUORODEOXYGLUCOSE
HISTOLOGY
IMAGES
LABELLED COMPOUNDS
LUNGS
LYMPH
NEOPLASMS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
UPTAKE