Staging of lung cancer by positron emission tomography
- Northern California PET Imaging Center, Sacramento, CA (United States); and others
Whole-body and static PET imaging with F-18-FDG was used to evaluate tumor stage in 26 patients with newly-diagnosed lung cancer. Tumor stage as determined by PET and by CT was compared to histologic findings. Tissue for diagnosis was obtained by mediastinoscopy and/or thoracotomy. Distant lesions were evaluated by biopsy and/or subsequent clinical progression. Not all tumor-involved lymph nodes were identified in some cases where PET showed mediastinal or hilar metastasis. The positive and negative predictive values for mediastinal or hilar disease were 88% and 94% respectively for PET, and 57% and 79% for CT. PET correctly identified distant metastases that were not detected by CT in 3 cases. One liver lesion and one contralateral lung lesion shown by CT proved to be benign. There were no false positive PET findings at distant sites, CT showed adrenal enlargement in 5 patients, whereas PET was abnormal in only one of these. Adrenal biopsy and/or sequential imaging confirmed the PET findings. Overall, PET changed the tumor stage as determined by CT in 9 patients (35%). PET demonstrated more extensive disease in 5 patients and less extensive disease in 4 patients. PET imaging was more accurate than CT in identifying patients who would not benefit from pulmonary resection.
- OSTI ID:
- 197945
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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