Precision of repeated quantitative FDG-PET scans in patients with untreated lung cancer

Journal Article · Sun May 01 04:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197942

Minn, H R.I.; Zasadny, K R; Quint, L E ^[1]

---

1. Univ. of Michigan, Ann Arbor, MI (United States); and others

The optimal mode for quantitation of F-18 fluorodeoxyglucose (FDG) uptake is uncertain when using PET in repeated studies of oncologic patients. We compared the reproducibility of the steady-state, graphical, and kinetic model derived FDG uptake measurements in six patients with primary lung cancer referred for thoracotomy. Prior to surgery, each patient underwent two 60 minute dynamic FDG-PET scans in the fasting state within three days. Images were analysed by placing 4x4 pixel ROIs over areas of maximum tumor tracer concentration and the left atrium (blood) to define kinetic uptake curves for tumor and blood FDG activity. {open_quotes}SUV lean{close_quotes} was determined based on tumor tracer concentration between 50-60 minutes from the injection corrected for injected activity and lean body mass. Graphically (KPatlak) and model (K1*k3/k2+k3) derived parameters for FDG uptake were calculated, as well as microrate constants (K1, k2 and k3). K4 was set=0 after initial studies showed it to be <0.01.

• OSTI ID: 197942
• Report Number(s): CONF-940605--
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
FLUORINE 18
FLUORODEOXYGLUCOSE
IMAGES
LABELLED COMPOUNDS
LUNGS
NEOPLASMS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
UPTAKE