Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants

Siwawannapong, Kittipan; Nemeth, Ansley M.; Melander, Roberta J.; Rong, Jie; Davis, Jonathan R.; Taniguchi, Masahiko; Carpenter, Morgan E.; Lindsey, Jonathan S.; Melander, Christian

doi:10.1002/cmdc.202200286

Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants

Journal Article · Wed Jun 15 00:00:00 EDT 2022 · ChemMedChem

DOI:https://doi.org/10.1002/cmdc.202200286· OSTI ID:1976305

Siwawannapong, Kittipan ^[1]; Nemeth, Ansley M. ^[2]; Melander, Roberta J. ^[2]; Rong, Jie ^[3]; Davis, Jonathan R. ^[3]; Taniguchi, Masahiko ^[3]; Carpenter, Morgan E. ^[2]; Lindsey, Jonathan S. ^[3]; ^[2]

North Carolina State University, Raleigh, NC (United States); OSTI
University of Notre Dame, IN (United States)
North Carolina State University, Raleigh, NC (United States)

Multidrug resistant (MDR) bacteria are an increasing public health problem. One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA-approved antibiotics that have been rendered ineffective due to resistance. In this study, we report a series of dipyrrins and pyrrole derivatives designed as analogues of prodigiosin and obatoclax, several of which potentiate the activity of colistin against Klebsiella pneumoniae, with lead compounds also potentiating colistin against Acinetobacter baumannii and Pseudomonas aeruginosa.

View Accepted Manuscript (DOE)

Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division (CSGB)

Grant/Contract Number:: FG02-05ER15661

OSTI ID:: 1976305

Journal Information:: ChemMedChem, Journal Name: ChemMedChem Journal Issue: 16 Vol. 17; ISSN 1860-7179

Publisher:: ChemPubSoc EuropeCopyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
adjuvant
antibiotic resistance
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gram negative

Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants

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References (21)

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