Microfabricated instruments for liquid phase analysis
- Oak Ridge National Lab., TN (United States)
The microfabrication of analytical instrumentation will potentially enable the laboratory to be transported to the samples rather than vice versa. Miniature chemical instrumentation can be based on conventional laboratory approaches to chemical measurement problems. Many laboratory-based procedures require sample manipulation prior to the actual measurement, and many analyses are fully automated to circumvent operator bias. Similarly, a portable instrument should have these sample preparatory steps incorporated into the design and function of the instrument. In addition, micromachined chemical instruments as opposed to single analyte chemical sensors should be able to identify and quantify all members of a desired class of compounds using a single device. The approach taken is to micromachine a channel manifold in a monolithic device that includes all desired fluid manipulation for complete chemical analysis. Chemical separation techniques including capillary electrophoresis, open channel electrochromatography and capillary electrophoresis with pre- and post-column derivatization have been demonstrated using microfabricated devices. The channel manifolds on the glass substrate are fabricated using standard photolithographic, etching and deposition techniques. Following the fabrication of the channels, a direct bonding technique is used to join the substrate and coverplate to form a network of closed channels for the experiments. Electrical control of the buffer, analyte and reagent streams makes possible the precise manipulation of the fluids within the channel manifold. The operation of these microchips consists of three elements: on-microchip chemical reactions, sample injection, and separation/detection. Each of these elements is evaluated.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 191667
- Report Number(s):
- CONF-941098-; TRN: 95:006733-0023
- Resource Relation:
- Conference: FACSS XXI: 21st annual conference of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), St. Louis, MO (United States), 2-7 Oct 1994; Other Information: PBD: 1994; Related Information: Is Part Of 21st annual conference of the Federation of Analytical Chemistry and Spectroscopy Societies; PB: 257 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis