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Breast cancer incidence following low-dose rate environmental exposure: Techa River Cohort, 1956–2004

Journal Article · · British Journal of Cancer
 [1];  [2];  [3];  [4];  [5];  [4];  [4]
  1. National Cancer Institute, Bethesda, MD (United States); Urals Research Center for Radiation Medicine, Chelyabinsk (Russia); OSTI
  2. Hirosoft International Corporation, Eureka, CA (United States)
  3. National Cancer Institute, Bethesda, MD (United States)
  4. Urals Research Center for Radiation Medicine, Chelyabinsk (Russia)
  5. University of Illinois, Chicago, IL (United States)
+ Show Author Affiliations
In the 1950s, the Mayak nuclear weapons facility in Russia discharged liquid radioactive wastes into the Techa River causing exposure of riverside residents to protracted low-to-moderate doses of radiation. Almost 10 000 women received estimated doses to the stomach of up to 0.47 Gray (Gy) (mean dose = 0.04 Gy) from external g-exposure and 137Cs incorporation. We have been following this population for cancer incidence and mortality and as in the general Russian population, we found a significant temporal trend of breast cancer incidence. A significant linear radiation dose–response relationship was observed (P = 0.01) with an estimated excess relative risk per Gray (ERR/Gy) of 5.00 (95% confidence interval (CI), 0.80, 12.76). We estimated that approximately 12% of the 109 observed cases could be attributed to radiation.
Research Organization:
University of Illinois, Chicago, IL (United States)
Sponsoring Organization:
Russian Federal Medical-Biological Agency; Russian Ministry of Health; USDOE
Grant/Contract Number:
FC02-04EH04014
OSTI ID:
1904869
Journal Information:
British Journal of Cancer, Journal Name: British Journal of Cancer Journal Issue: 11 Vol. 99; ISSN 0007-0920
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English

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Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983–2008 journal September 2016

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Related Subjects

60 APPLIED LIFE SCIENCES
Techa River
breast cancer
incidence
ionising radiation
low-dose rate exposure