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Leukaemia incidence in the Techa River Cohort: 1953–2007

Journal Article · · British Journal of Cancer
DOI:https://doi.org/10.1038/bjc.2013.614· OSTI ID:1623740
 [1];  [2];  [3];  [4];  [5];  [5];  [5]
  1. Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation). Epidemiology Lab.; DOE/OSTI
  2. Univ. of Illinois, Chicago, IL (United States). School of Public Health, Division of Epidemiology/Biostatistics
  3. International Agency for Research on Cancer, Lyon (France). Section of Environment and Radiation; National Cancer Institute, Bethesda, MD (United States). Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics
  4. Hirosoft International Company, Eureka, CA (United States)
  5. Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation). Epidemiology Lab.
+ Show Author Affiliations
Background: Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks associated with chronic low-dose-rate internal and external exposures. Methods: Excess relative risk models described the dose–response relationship between radiation dose on the basis of updated dose estimates and the incidence of haematological malignancies ascertained between 1953 and 2007 among 28 223 cohort members, adjusted for attained age, sex, and other factors. Results: Almost half of the 72 leukaemia cases (excluding chronic lymphocytic leukaemia (CLL)) were estimated to be associated with radiation exposure. These data are consistent with a linear dose response with no evidence of modification. The excess relative risk estimate was 0.22 per 100 mGy. There was no evidence of significant dose effect for CLL or other haematopoietic malignancies. Conclusion: These analyses demonstrate that radiation exposures, similar to those received by populations exposed as a consequence of nuclear accidents, are associated with long-term dose-related increases in leukaemia risks. Using updated dose estimates, the leukaemia risk per unit dose is about half of that based on previous dosimetry.
Research Organization:
Univ. of Illinois, Chicago, IL (United States)
Sponsoring Organization:
Russian Ministry of Health; USDOE Office of Environment, Health, Safety and Security (AU)
OSTI ID:
1623740
Journal Information:
British Journal of Cancer, Journal Name: British Journal of Cancer Journal Issue: 11 Vol. 109; ISSN 0007-0920
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English

References (40)

Leukemia incidence among people exposed to chronic radiation from the contaminated Techa River, 1953–2005 journal December 2009
Leukemia incidence in the Russian cohort of Chernobyl emergency workers journal January 2012
A record-based case–control study of natural background radiation and the incidence of childhood leukaemia and other cancers in Great Britain during 1980–2006 journal June 2012
Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers journal January 2009
Ionising radiation and cancer risks: What have we learned from epidemiology? journal January 2009
Risk analysis of leukaemia incidence among people living along the Techa River: a nested case-control study journal March 2006
What is a low dose? Response to "Reply to 'The RBE of low-LET radiations' " Reply to the Response to "Reply to 'The RBE of low-LET radiations' " Comment on 'Updated estimates of the proportion of childhood leukaemia incidence in Great Britain that may be caused by natural background ionising radiation' Reply to "Comment on 'Updated estimates of the proportion of childhood leukaemia incidence in Great Britain that may be caused by natural background ionising radiation' " journal March 2010
Commentary: Low dose-rate exposures to ionizing radiation journal September 2007
Relationship of Leukemia Risk to Radiation Dose Following Cancer of the Uterine Corpus journal September 1994
An approach to reduction of uncertainties in internal doses reconstructed for the Techa river population journal June 2007
Dose Reconstruction System for the Exposed Population Living Along the Techa River journal January 2000
The Techa River Dosimetry System: Methods for the Reconstruction of Internal dose journal January 2000
Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90 journal January 2011
Reevaluation of Waterborne Releases of Radioactive Materials from the Mayak Production Association into the Techa River in 1949–1951 journal January 2012
Radiation and the Risk of Chronic Lymphocytic and Other Leukemias among Chornobyl Cleanup Workers journal January 2013
Evaluation of Age and Gender Dependences of the Rate of Strontium Elimination 25–45 Years after Intake: Analysis of Data from Residents Living along the Techa River journal February 2003
The Incidence of Leukemia, Lymphoma and Multiple Myeloma among Atomic Bomb Survivors: 1950–2001 journal February 2013
Development of an Improved Dose Reconstruction System for the Techa River Population Affected by the Operation of the Mayak Production Association journal July 2006
The Techa River Cohort: Study Design and Follow-up Methods journal November 2005
Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort journal November 2005
Cancer risks associated with external radiation from diagnostic imaging procedures journal February 2012
Reconstruction of the contamination of the Techa River in 1949–1951 as a result of releases from the “MAYAK” Production Association journal July 2012
Numbers and proportions of leukemias in young people and adults induced by radiation of natural origin journal August 2011
The meaning of low dose and low dose-rate journal March 2010
Solid cancer incidence and low-dose-rate radiation exposures in the Techa River cohort: 1956 2002 journal September 2007
Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90 journal January 2011
Reevaluation of Waterborne Releases of Radioactive Materials from the Mayak Production Association into the Techa River in 1949–1951 journal January 2012
A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation journal October 2010
Theoretical Statistics book January 1974
Evaluation of Age and Gender Dependences of the Rate of Strontium Elimination 25–45 Years after Intake: Analysis of Data from Residents Living along the Techa River journal February 2003
Cancer Mortality Risk among Workers at the Mayak Nuclear Complex journal June 2003
Risk of Hematological Malignancies among Chernobyl Liquidators journal December 2008
The Incidence of Leukemia, Lymphoma and Multiple Myeloma among Atomic Bomb Survivors: 1950–2001 journal February 2013
Solid Cancer Mortality in the Techa River Cohort (1950–2007) journal February 2013
Development of an Improved Dose Reconstruction System for the Techa River Population Affected by the Operation of the Mayak Production Association journal July 2006
The Techa River Cohort: Study Design and Follow-up Methods journal November 2005
Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort journal November 2005
Individual Dose Calculations with Use of the Revised Techa River Dosimetry System TRDS-2009D report October 2009
Cancer Incidence in Atomic Bomb Survivors. Part III: Leukemia, Lymphoma and Multiple Myeloma, 1950-1987 journal February 1994
Radiation and the Risk of Chronic Lymphocytic and Other Leukemias among Chornobyl Cleanup Workers text January 2013

Cited By (12)

DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences journal January 2017
Typical doses and dose rates in studies pertinent to radiation risk inference at low doses and low dose rates journal February 2018
It Is Time to Move Beyond the Linear No-Threshold Theory for Low-Dose Radiation Protection journal July 2018
Effect of 90Sr internal emitter on gene expression in mouse blood journal August 2015
γ-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90 journal November 2015
Radiation Risks of Leukemia, Lymphoma and Multiple Myeloma Incidence in the Mayak Cohort: 1948–2004 journal September 2016
NOD Scid Gamma Mice Are Permissive to Allogeneic HSC Transplantation without Prior Conditioning journal November 2016
Clinical characteristics of chronic lymphocytic leukemia occurring in chornobyl cleanup workers: CLL in chornobyl cleanup workers journal January 2016
Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection journal August 2018
Leukaemia mortality and low-dose ionising radiation in the WISMUT uranium miner cohort (1946–2013) journal November 2016
Effect of 90Sr internal emitter on gene expression in mouse blood text January 2015
γ-H2AX Kinetic Profile in Mouse Lymphocytes Exposed to the Internal Emitters Cesium-137 and Strontium-90 text January 2015

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
cohort
environmental exposure
haematological malignancies
ionising radiation
leukaemia
oncology
strontium