Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice

Jangiam, Witawat; Udomtanakunchai, Chatchanok; Reungpatthanaphong, Paiboon; Tungjai, Montree; Honikel, Louise; Gordon, Chris R.; Rithidech, Kanokporn Noy

doi:10.1177/1559325818815031

Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice

Journal Article · Tue Dec 18 23:00:00 EST 2018 · Dose-Response

DOI:https://doi.org/10.1177/1559325818815031· OSTI ID:1904756

Jangiam, Witawat ^[1]; Udomtanakunchai, Chatchanok ^[2]; Reungpatthanaphong, Paiboon ^[3]; Tungjai, Montree ^[2]; Honikel, Louise ^[4]; Gordon, Chris R. ^[4]; Rithidech, Kanokporn Noy ^[4]

Stony Brook University, Stony Brook, NY, (United States); Burapha University, Chonburi (Thailand); Stony Brook Univ., NY (United States)
Stony Brook University, Stony Brook, NY, (United States); Chiang Mai University, Chiang Mai (Thailand)
Stony Brook University, Stony Brook, NY, (United States); Kasetsart University, Bangkok (Thailand)
Stony Brook University, Stony Brook, NY, (United States)

We used 3 biological metrics highly relevant to health risks, that is, cell death, inflammation, and global DNA methylation, to determine the late effects of low doses (0.05 or 0.1 Gy) of ¹³⁷Cs γ rays on the bone marrow, lung, and testis collected at 6 months post-irradiation from the same exposed BALB/cJ mouse. This integrative approach has not been used for such a purpose. Mice exposed to 0 or 1 Gy of radiation served as a sham or positive control group, respectively. The results could deliver information for better health risk assessment across tissues, including better scientific basis for radiation protection and clinical application. We found no changes in the levels of all studied biological metrics (except a significant increase in the levels of an anti-inflammatory cytokine, ie, interleukin 10) in tissues of 0.05-Gy exposed mice, when compared to those in sham controls. In contrast, significantly increased levels of cell death and inflammation, including a significant loss of global 5-hydroxymethylcytosine, were found in all tissues of the same mice exposed to 0.1 or 1.0 Gy. Our data demonstrated not only no harm but also hormesis in the 0.05-Gy exposed mice. However, the hormetic effect appears to be dependent on biological metrics and tissue.

View Accepted Manuscript (DOE)

Research Organization:: Stony Brook University, Stony Brook, NY, (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Aeronautics and Space Administration (NASA); Stony Brook University

Grant/Contract Number:: FG02-02ER63311

OSTI ID:: 1904756

Journal Information:: Dose-Response, Journal Name: Dose-Response Journal Issue: 4 Vol. 16; ISSN 1559-3258

Publisher:: International Hormesis SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Supplemental Material, Table_1_word_format - Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice Jangiam, Witawat; Udomtanakunchai, Chatchanok; Reungpatthanaphong, Paiboon https://doi.org/10.25384/sage.7491719 The current record is supplemented by this text	text	January 2018
Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice Jangiam, Witawat; Udomtanakunchai, Chatchanok; Reungpatthanaphong, Paiboon https://doi.org/10.25384/sage.c.4342862.v1 The current record is supplemented by this collection	collection	January 2018

Late Effects of Low-Dose Radiation on the Bone Marrow, Lung, and Testis Collected From the Same Exposed BALB/cJ Mice

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