The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

Schierwater, Bernd; Kamm, Kai; Srivastava, Mansi; Rokhsar, Daniel; Rosengarten, Rafael D.; Dellaporta, Stephen L.

doi:10.1371/journal.pone.0002457

Title: The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

Journal Article · Thu Aug 21 00:00:00 EDT 2008 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0002457· OSTI ID:1904079

Schierwater, Bernd ^[1]; Kamm, Kai ^[2]; Srivastava, Mansi ^[3]; Rokhsar, Daniel ^[4]; Rosengarten, Rafael D. ^[5]; Dellaporta, Stephen L. ^[5]

Stiftung Tieraerztliche Hochschule Hannover (Germany); Yale Univ., New Haven, CT (United States)
Stiftung Tieraerztliche Hochschule Hannover (Germany)
Univ. of California, Berkeley, CA (United States)
USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Univ. of California, Berkeley, CA (United States)
Yale Univ., New Haven, CT (United States)

The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals. Whole genome sequences have recently filled in some crucial gaps for the basal metazoan phyla Cnidaria and Porifera. Here we analyze the complete genome of Trichoplax adhaerens, representing the basal metazoan phylum Placozoa, for its set of ANTP class genes. The Trichoplax genome encodes representatives of Hox/ParaHox-like, NKL, and extended Hox genes. This repertoire possibly mirrors the condition of a hypothetical cnidarian-bilaterian ancestor. The evolution of the cnidarian and bilaterian ANTP gene repertoires can be deduced by a limited number of cis-duplications of NKL and “extended Hox” genes and the presence of a single ancestral “ProtoHox” gene.

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Research Organization:: USDOE Joint Genome Institute (JGI), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF); Human Frontier Science Program; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231; RR19895; RGP 0221

OSTI ID:: 1904079

Journal Information:: PLoS ONE, Vol. 3, Issue 8; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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