Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Zhang, Jinyuan; Kim, Kyunghun; Kim, Ho Joong; Meyer, Dawn; Park, Woohyun; Lee, Seul Ah; Dai, Yumin; Kim, Bongjoong; Moon, Haesoo; Shah, Jay V.; Harris, Keely E.; Collar, Brett; Liu, Kangying; Irazoqui, Pedro; Lee, Hyowon; Park, Shin Ae; Kollbaum, Pete S.; Boudouris, Bryan W.; Lee, Chi Hwan

doi:10.1038/s41467-022-33254-4

Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Journal Article · Tue Sep 20 00:00:00 EDT 2022 · Nature Communications

DOI:https://doi.org/10.1038/s41467-022-33254-4· OSTI ID:1903256

Zhang, Jinyuan ^[1]; Kim, Kyunghun ^[2]; Kim, Ho Joong ^[2]; Meyer, Dawn ^[3]; ^[2]; Lee, Seul Ah ^[2]; Dai, Yumin ^[2]; Kim, Bongjoong ^[4]; Moon, Haesoo ^[2]; Shah, Jay V. ^[2]; Harris, Keely E. ^[2]; Collar, Brett ^[5]; Liu, Kangying ^[2]; Irazoqui, Pedro ^[5]; ^[2]; ^[2]; ^[6]; ^[2]; ^[6]

Purdue Univ., West Lafayette, IN (United States); Purdue University
Purdue Univ., West Lafayette, IN (United States)
Indiana Univ., Bloomington, IN (United States)
Purdue Univ., West Lafayette, IN (United States); Hongik Univ., Seoul (Korea, Republic of)
Johns Hopkins Univ., Baltimore, MD (United States)
Purdue Univ., West Lafayette, IN (United States); Indiana Univ., Bloomington, IN (United States)

Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.

View Accepted Manuscript (DOE)

Research Organization:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: SC0021967

OSTI ID:: 1903256

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 13; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

References (51)

The Pathophysiology and Treatment of Glaucoma Weinreb, Robert N.; Aung, Tin; Medeiros, Felipe A. JAMA, Vol. 311, Issue 18 https://doi.org/10.1001/jama.2014.3192	journal	May 2014
Measured Changes in Limbal Strain During Simulated Sleep in Face Down Position Using an Instrumented Contact Lens in Healthy Adults and Adults With Glaucoma Flatau, Alison; Solano, Francisco; Idrees, Sana JAMA Ophthalmology, Vol. 134, Issue 4 https://doi.org/10.1001/jamaophthalmol.2015.5667	journal	April 2016
Measurement of Intraocular Pressure by Patients With Glaucoma Pronin, Savva; Brown, Lyndsay; Megaw, Roly JAMA Ophthalmology, Vol. 135, Issue 10 https://doi.org/10.1001/jamaophthalmol.2017.3151	journal	October 2017
An Ultrasensitive Contact Lens Sensor Based On Self‐Assembly Graphene For Continuous Intraocular Pressure Monitoring Liu, Zhiduo; Wang, Gang; Ye, Chen Advanced Functional Materials, Vol. 31, Issue 29 https://doi.org/10.1002/adfm.202010991	journal	May 2021
Contact Lens Sensors in Ocular Diagnostics Farandos, Nicholas M.; Yetisen, Ali K.; Monteiro, Michael J. Advanced Healthcare Materials, Vol. 4, Issue 6 https://doi.org/10.1002/adhm.201400504	journal	November 2014
Printing Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems Kim, Kyunghun; Kim, Bongjoong; Lee, Chi Hwan Advanced Materials https://doi.org/10.1002/adma.201902051	journal	July 2019
Recent Advances in Smart Contact Lenses Kim, Joohee; Cha, Eunkyung; Park, Jang‐Ung Advanced Materials Technologies, Vol. 5, Issue 1 https://doi.org/10.1002/admt.201900728	journal	November 2019
The pressure difference between eye and brain changes with posture Eklund, Anders; Jóhannesson, Gauti; Johansson, Elias Annals of Neurology, Vol. 80, Issue 2 https://doi.org/10.1002/ana.24713	journal	July 2016
Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial Garway-Heath, David F.; Crabb, David P.; Bunce, Catey The Lancet, Vol. 385, Issue 9975 https://doi.org/10.1016/S0140-6736(14)62111-5	journal	April 2015
Glaucoma Jonas, Jost B.; Aung, Tin; Bourne, Rupert R. The Lancet, Vol. 390, Issue 10108 https://doi.org/10.1016/S0140-6736(17)31469-1	journal	November 2017
Soft contact lens polymers: an evolution Nicolson, Paul C.; Vogt, Jürgen Biomaterials, Vol. 22, Issue 24 https://doi.org/10.1016/S0142-9612(01)00165-X	journal	December 2001
Tissue and cellular biomechanics during corneal wound injury and repair Raghunathan, Vijay Krishna; Thomasy, Sara M.; Strøm, Peter Acta Biomaterialia, Vol. 58 https://doi.org/10.1016/j.actbio.2017.05.051	journal	August 2017
Effect of Different Head Positions in Lateral Decubitus Posture on Intraocular Pressure in Treated Patients With Open-Angle Glaucoma Lee, Tae-Eun; Yoo, Chungkwon; Lin, Shan C. American Journal of Ophthalmology, Vol. 160, Issue 5 https://doi.org/10.1016/j.ajo.2015.07.030	journal	November 2015
What We Have Learned From the Ocular Hypertension Treatment Study Gordon, Mae O.; Kass, Michael A. American Journal of Ophthalmology, Vol. 189 https://doi.org/10.1016/j.ajo.2018.02.016	journal	May 2018
Comparison of patient-reported visual outcome methods to quantify the perceptual effects of defocus Kollbaum, Pete S.; Jansen, Meredith E.; Rickert, Martin E. Contact Lens and Anterior Eye, Vol. 35, Issue 5 https://doi.org/10.1016/j.clae.2012.05.001	journal	October 2012
Giant papillary conjunctivitis: A review Kenny, Sarah E.; Tye, Cooper B.; Johnson, Daniel A. The Ocular Surface, Vol. 18, Issue 3 https://doi.org/10.1016/j.jtos.2020.03.007	journal	July 2020
Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors Guo, Shiqi; Wu, Kaijin; Li, Chengpan Matter, Vol. 4, Issue 3 https://doi.org/10.1016/j.matt.2020.12.002	journal	March 2021
Effects of Different Sleeping Postures on Intraocular Pressure and Ocular Perfusion Pressure in Healthy Young Subjects Lee, Tae-Eun; Yoo, Chungkwon; Kim, Yong Yeon Ophthalmology, Vol. 120, Issue 8 https://doi.org/10.1016/j.ophtha.2013.01.011	journal	August 2013
Normal-Tension Glaucoma Has Normal Intracranial Pressure Lindén, Christina; Qvarlander, Sara; Jóhannesson, Gauti Ophthalmology, Vol. 125, Issue 3 https://doi.org/10.1016/j.ophtha.2017.09.022	journal	March 2018
24-h monitoring devices and nyctohemeral rhythms of intraocular pressure Aptel, Florent; Weinreb, Robert N.; Chiquet, Christophe Progress in Retinal and Eye Research, Vol. 55 https://doi.org/10.1016/j.preteyeres.2016.07.002	journal	November 2016
Discovery and clinical translation of novel glaucoma biomarkers Beykin, Gala; Norcia, Anthony M.; Srinivasan, Vivek J. Progress in Retinal and Eye Research, Vol. 80 https://doi.org/10.1016/j.preteyeres.2020.100875	journal	January 2021
Gas-Permeable, Irritation-Free, Transparent Hydrogel Contact Lens Devices with Metal-Coated Nanofiber Mesh for Eye Interfacing Wei, Shiyuan; Yin, Rongkang; Tang, Tao ACS Nano, Vol. 13, Issue 7 https://doi.org/10.1021/acsnano.9b02305	journal	June 2019
Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics Kim, Joohee; Kim, Minji; Lee, Mi-Sun Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14997	journal	April 2017
High resolution non-invasive intraocular pressure monitoring by use of graphene woven fabrics on contact lens Zhang, Yushi; Chen, Yufeng; Man, Tianxing Microsystems & Nanoengineering, Vol. 5, Issue 1 https://doi.org/10.1038/s41378-019-0078-x	journal	August 2019
What is the best way to measure intraocular pressure (IOP) in a virtual clinic? Mostafa, Islam; Bianchi, Eleonora; Brown, Lyndsay Eye, Vol. 35, Issue 2 https://doi.org/10.1038/s41433-020-0868-2	journal	April 2020
Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility Chintalapudi, Sumana R.; Maria, Doaa; Di Wang, Xiang Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00837-5	journal	November 2017
Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram Yin, Rongkang; Xu, Zheng; Mei, Ming Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04781-w	journal	June 2018
All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis Kim, Kyunghun; Kim, Ho Joong; Zhang, Haozhe Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-21916-8	journal	March 2021
A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery Hu, Shanshan; Pei, Xibo; Duan, Lunliang Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-21989-5	journal	March 2021
Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging Kim, Bongjoong; Soepriatna, Arvin H.; Park, Woohyun Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-23959-3	journal	June 2021
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure Kim, Joohee; Park, Jihun; Park, Young-Geun Nature Biomedical Engineering, Vol. 5, Issue 7 https://doi.org/10.1038/s41551-021-00719-8	journal	May 2021
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays Wang, Chonghe; Qi, Baiyan; Lin, Muyang Nature Biomedical Engineering, Vol. 5, Issue 7 https://doi.org/10.1038/s41551-021-00763-4	journal	July 2021
Materials for flexible bioelectronic systems as chronic neural interfaces Song, Enming; Li, Jinghua; Won, Sang Min Nature Materials, Vol. 19, Issue 6 https://doi.org/10.1038/s41563-020-0679-7	journal	May 2020
Skin-integrated wireless haptic interfaces for virtual and augmented reality Yu, Xinge; Xie, Zhaoqian; Yu, Yang Nature, Vol. 575, Issue 7783 https://doi.org/10.1038/s41586-019-1687-0	journal	November 2019
Generalized parity–time symmetry condition for enhanced sensor telemetry Chen, Pai-Yen; Sakhdari, Maryam; Hajizadegan, Mehdi Nature Electronics, Vol. 1, Issue 5 https://doi.org/10.1038/s41928-018-0072-6	journal	May 2018
Three-dimensional integrated stretchable electronics Huang, Zhenlong; Hao, Yifei; Li, Yang Nature Electronics, Vol. 1, Issue 8 https://doi.org/10.1038/s41928-018-0116-y	journal	August 2018
Three-dimensional curvy electronics created using conformal additive stamp printing Sim, Kyoseung; Chen, Song; Li, Zhengwei Nature Electronics, Vol. 2, Issue 10 https://doi.org/10.1038/s41928-019-0304-4	journal	September 2019
Wireless, passive strain sensor in a doughnut-shaped contact lens for continuous non-invasive self-monitoring of intraocular pressure M. Kouhani, M. Hossein; Wu, Jiajia; Tavakoli, Arman Lab on a Chip, Vol. 20, Issue 2 https://doi.org/10.1039/C9LC00735K	journal	January 2020
Application of graphene nanowalls in an intraocular pressure sensor Liu, Zhiduo; Wang, Gang; Pei, Weihua Journal of Materials Chemistry B, Vol. 8, Issue 38 https://doi.org/10.1039/D0TB01687J	journal	January 2020
In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model Li, Guorong; Lee, Chanyoung; Agrahari, Vibhuti Proceedings of the National Academy of Sciences, Vol. 116, Issue 5 https://doi.org/10.1073/pnas.1814889116	journal	January 2019
Can the SENSIMED Triggerfish^® lens data be used as an accurate measure of intraocular pressure? Vitish-Sharma, Parveen; Acheson, Austin G.; Stead, Richard Acta Ophthalmologica, Vol. 96, Issue 2 https://doi.org/10.1111/aos.13456	journal	April 2017
Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays Park, Jihun; Kim, Joohee; Kim, So-Yun Science Advances, Vol. 4, Issue 1 https://doi.org/10.1126/sciadv.aap9841	journal	January 2018
Printing of wirelessly rechargeable solid-state supercapacitors for soft, smart contact lenses with continuous operations Park, Jihun; Ahn, David B.; Kim, Joohee Science Advances, Vol. 5, Issue 12 https://doi.org/10.1126/sciadv.aay0764	journal	December 2019
Wireless smart contact lens for diabetic diagnosis and therapy Keum, Do Hee; Kim, Su-Kyoung; Koo, Jahyun Science Advances, Vol. 6, Issue 17 https://doi.org/10.1126/sciadv.aba3252	journal	April 2020
Smart, soft contact lens for wireless immunosensing of cortisol Ku, Minjae; Kim, Joohee; Won, Jong-Eun Science Advances, Vol. 6, Issue 28 https://doi.org/10.1126/sciadv.abb2891	journal	July 2020
Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles Jang, Jiuk; Kim, Joohee; Shin, Haein Science Advances, Vol. 7, Issue 14 https://doi.org/10.1126/sciadv.abf7194	journal	April 2021
Eye problems in contact lens wearers Shahid, Syed M.; Ahmed, Syed N.; Khan, Yusra BMJ https://doi.org/10.1136/bmj.l6337	journal	November 2019
Animal Models of Glaucoma A. Bouhenni, Rachida; Dunmire, Jeffrey; Sewell, Abby Journal of Biomedicine and Biotechnology, Vol. 2012 https://doi.org/10.1155/2012/692609	journal	January 2012
Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies Langevin, Nicholas E.; Schafer, Kenneth A.; Turner, Oliver C. Toxicologic Pathology, Vol. 46, Issue 7 https://doi.org/10.1177/0192623318803854	journal	October 2018
Ocular rigidity Pallikaris, Ioannis G.; Dastiridou, Anna I.; Tsilimbaris, Miltiadis K. Expert Review of Ophthalmology, Vol. 5, Issue 3 https://doi.org/10.1586/eop.10.30	journal	June 2010
The Sensimed Triggerfish contact lens sensor: efficacy, safety, and patient perspectives Dunbar, Grace E.; Shen, Bailey; Aref, Ahmad Clinical Ophthalmology, Vol. Volume 11 https://doi.org/10.2147/OPTH.S109708	journal	May 2017

Similar Records

Controlled five-year follow-up study of laser trabeculoplasty as primary therapy for open-angle glaucoma

Journal Article · Thu Oct 15 00:00:00 EDT 1987 · Am. J. Ophthalmol.; (United States) · OSTI ID:5628690

Treatment of absolute painful glaucoma with dynamic arcs using novalis shaped beam radiosurgery

Journal Article · Tue Nov 14 23:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:20850194

Molecular genetics of the glaucomas: Mapping of the first five {open_quotes}GLC{close_quotes} loci

Journal Article · Fri Jan 31 23:00:00 EST 1997 · American Journal of Human Genetics · OSTI ID:518505

Related Subjects

36 MATERIALS SCIENCE
Biomedical engineering
Biomedical materials
Health care
Visual system

Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Citation Formats

References (51)

Similar Records

Related Subjects