Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors

Hu, Dennis X.; Patel, Snahel; Chen, Huifen; Wang, Shumei; Staben, Steven T.; Dimitrova, Yoana N.; Wallweber, Heidi Ackerly; Lee, Joanna Y.; Chan, Grace Ka Yan; Sneeringer, Christopher J.; Prangley, Madeleine S.; Moffat, John G.; Wu, Kai C.; Schutt, Leah K.; Salphati, Laurent; Pang, Jodie; McNamara, Erin; Huang, Haochu; Chen, Yong; Wang, Yunli; Zhao, Wensheng; Lim, Junghyun; Murthy, Aditya; Siu, Michael

doi:10.1021/acs.jmedchem.1c01180

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors

Journal Article · 01 January 2022 · J. Med. Chem.

DOI:https://doi.org/10.1021/acs.jmedchem.1c01180· OSTI ID:1900949

Hu, Dennis X.; Patel, Snahel; Chen, Huifen; Wang, Shumei; Staben, Steven T.; Dimitrova, Yoana N.; Wallweber, Heidi Ackerly; Lee, Joanna Y.; Chan, Grace Ka Yan; Sneeringer, Christopher J.; Prangley, Madeleine S.; Moffat, John G.; Wu, Kai C.; Schutt, Leah K.; Salphati, Laurent; Pang, Jodie; McNamara, Erin; Huang, Haochu; Chen, Yong; Wang, Yunli more »

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1900949

Journal Information:: J. Med. Chem., Vol. 65, Issue (17)

Country of Publication:: United States

Language:: ENGLISH

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