Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR an

Xu, Guozhang; Searle, Lily Lee; Hughes, Terry V.; Beck, Amanda K.; Connolly, Peter J.; Abad, Marta C.; Neeper, Michael P.; Struble, Geoffrey T.; Springer, Barry A.; Emanuel, Stuart L.; Gruninger, Robert H.; Pandey, Niranjan; Adams, Mary; Moreno-Mazza, Sandra; Fuentes-Pesquera, Angel R.; Middleton, Steven A.; Greenberger, Lee M.

doi:10.1016/j.bmcl.2008.05.024

Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR an

Journal Article · Sun Jun 01 00:00:00 EDT 2008 · Bioorg. Med. Chem. Lett.

DOI:https://doi.org/10.1016/j.bmcl.2008.05.024· OSTI ID:1900743

Xu, Guozhang; Searle, Lily Lee; Hughes, Terry V.; Beck, Amanda K.; Connolly, Peter J.; Abad, Marta C.; Neeper, Michael P.; Struble, Geoffrey T.; Springer, Barry A.; Emanuel, Stuart L.; Gruninger, Robert H.; Pandey, Niranjan; Adams, Mary; Moreno-Mazza, Sandra; Fuentes-Pesquera, Angel R.; Middleton, Steven A.; Greenberger, Lee M.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1900743

Journal Information:: Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (12) Vol. 18

Country of Publication:: United States

Language:: ENGLISH

References (20)

Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors Huang, Shenlin; Li, Ronghua; Connolly, Peter J. Bioorganic & Medicinal Chemistry Letters, Vol. 16, Issue 23 https://doi.org/10.1016/j.bmcl.2006.08.107	journal	December 2006
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases Mastalerz, Harold; Chang, Ming; Chen, Ping Bioorganic & Medicinal Chemistry Letters, Vol. 17, Issue 7 https://doi.org/10.1016/j.bmcl.2007.01.002	journal	April 2007
A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models Emanuel, Stuart; Gruninger, Robert H.; Fuentes-Pesquera, Angel Molecular Pharmacology, Vol. 66, Issue 3 https://doi.org/10.1124/mol.104.000638	journal	June 2004
Pd/C mediated synthesis of 2-substituted benzo[b]furans/nitrobenzo[b]furans in water Pal, Manojit; Subramanian, Venkataraman; Yeleswarapu, Koteswar Rao Tetrahedron Letters, Vol. 44, Issue 45 https://doi.org/10.1016/j.tetlet.2003.09.080	journal	November 2003
The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy Woodburn, J. R. Pharmacology & Therapeutics, Vol. 82, Issue 2-3 https://doi.org/10.1016/S0163-7258(98)00045-X	journal	May 1999
Epidermal growth factor-related peptides and their receptors in human malignancies Salomon, David S.; Brandt, Ralf; Ciardiello, Fortunato Critical Reviews in Oncology/Hematology, Vol. 19, Issue 3 https://doi.org/10.1016/1040-8428(94)00144-I	journal	July 1995
Synthesis of 2-substituted benzimidazole-5-carbamates as potential antifilarial agents Ram, Siya; Wise, Dean S.; Townsend, LeRoy B. Journal of Heterocyclic Chemistry, Vol. 23, Issue 4 https://doi.org/10.1002/jhet.5570230430	journal	July 1986
Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2 Cockerill, Stuart; Stubberfield, Colin; Stables, Jeremy Bioorganic & Medicinal Chemistry Letters, Vol. 11, Issue 11 https://doi.org/10.1016/S0960-894X(01)00219-0	journal	June 2001
Role of an Anti-epidermal Growth Factor Receptor in Treating Cancer Waksal, Harlan W. Cancer and Metastasis Reviews, Vol. 18, Issue 4, p. 427-436 https://doi.org/10.1023/A:1006302101468	journal	January 1999
Comparison of the Biochemical and Kinetic Properties of the Type 1 Receptor Tyrosine Kinase Intracellular Domains Brignola, Perry S.; Lackey, Karen; Kadwell, Sue H. Journal of Biological Chemistry, Vol. 277, Issue 2 https://doi.org/10.1074/jbc.M105907200	journal	January 2002
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer Olayioye, M. A. The EMBO Journal, Vol. 19, Issue 13 https://doi.org/10.1093/emboj/19.13.3159	journal	July 2000
4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors Gaul, Micheal D.; Xu, Guozhang; Kirkpatrick, Jennifer Bioorganic & Medicinal Chemistry Letters, Vol. 17, Issue 17 https://doi.org/10.1016/j.bmcl.2007.06.046	journal	September 2007
Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors Liao, Jeffrey Jie-Lou Journal of Medicinal Chemistry, Vol. 50, Issue 3 https://doi.org/10.1021/jm0608107	journal	February 2007
Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung Journal of Medicinal Chemistry, Vol. 45, Issue 17 https://doi.org/10.1021/jm020049a	journal	July 2002
Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines Gaul, Micheal D.; Guo, Yu; Affleck, Karen Bioorganic & Medicinal Chemistry Letters, Vol. 13, Issue 4 https://doi.org/10.1016/S0960-894X(02)01047-8	journal	February 2003
Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor Stamos, Jennifer; Sliwkowski, Mark X.; Eigenbrot, Charles Journal of Biological Chemistry, Vol. 277, Issue 48 https://doi.org/10.1074/jbc.M207135200	journal	August 2002
Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor Bhattacharya, Samit K.; Cox, Eric D.; Kath, John C. Biochemical and Biophysical Research Communications, Vol. 307, Issue 2 https://doi.org/10.1016/S0006-291X(03)01160-4	journal	July 2003
Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers Gullick, W. J. British Medical Bulletin, Vol. 47, Issue 1 https://doi.org/10.1093/oxfordjournals.bmb.a072464	journal	January 1991
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. Baselga, J.; Tripathy, D.; Mendelsohn, J. Journal of Clinical Oncology, Vol. 14, Issue 3 https://doi.org/10.1200/JCO.1996.14.3.737	journal	March 1996
Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity Tsou, Hwei-Ru; Overbeek-Klumpers, Elsebe G.; Hallett, William A. Journal of Medicinal Chemistry, Vol. 48, Issue 4 https://doi.org/10.1021/jm040159c	journal	February 2005

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